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F9427

Sigma-Aldrich

Fexofenadine hydrochloride

>98% (HPLC), H1 histamine receptor antagonist, powder

Synonym(s):

Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine carboxylate hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C32H39NO4 · HCl
CAS Number:
153439-40-8
Molecular Weight:
538.12
MDL number:
MFCD00865710
UNSPSC Code:
12352200
PubChem Substance ID:
24278447
NACRES:
NA.77

Key Documents

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Product Name

Fexofenadine hydrochloride, >98% (HPLC)

Quality Level

100

assay

>98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: soluble ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

−20°C

SMILES string

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

InChI key

RRJFVPUCXDGFJB-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Application

Fexofenadine hydrochloride has been used as a non-cationic ampliphilic antihistamines in NCI-H661 cells and as a histamine H1 receptor antagonist in mice

Biochem/physiol Actions

Fexofenadine is a non-sedating H1 histamine receptor antagonist.
Fexofenadine is used in treating allergic rhinitis and chronic idiopathic urticaria. It may give relief in bothersome symptom and is a second-generation antihistamines. Fexofenadine provides better relief compared to other antihistamines for nasal congestion. It is the active metabolite of terfenadine and bring down allergen-induced symptoms.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
026M4768V
035M4734V
022M4706V
020M47162V
020M47161

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Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function
Dicpinigaitis PV and Gayle YE
British Journal of Clinical Pharmacology, 56(5), 501-504 (2003)
Jürgen Brüning et al.
The Journal of pharmacy and pharmacology, 67(6), 773-781 (2015-02-14)
This study describes the general method for the determination of the crystal structures of active pharmaceutical ingredients (API) from powder diffraction data and demonstrates its use to determine the hitherto unknown crystal structure of fexofenadine hydrochloride, a third-generation antihistamine drug.
Inhibitory effect of oblongifolin C on allergic inflammation through the suppression of mast cell activation
Lu Y, et al.
Molecular and Cellular Biochemistry, 406(1-2), 263-271 (2015)
A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis
Bachert C
Clinical Therapeutics, 31(5), 921-944 (2009)
Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability
Lappin G, et al.
European Journal of Pharmaceutical Sciences, 40(2), 125-131 (2010)
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