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D127

Sigma-Aldrich

Dextrorphan tartrate

NMDA-receptor antagonist, powder

Synonym(s):

(+)-3-Hydroxy-N-methylmorphinan (+)-tartrate salt, Dextrorphan D-tartrate

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About This Item

Empirical Formula (Hill Notation):
C17H23NO · C4H6O6
CAS Number:
143-98-6
Molecular Weight:
407.46
MDL number:
MFCD00151495
UNSPSC Code:
12352200
PubChem Substance ID:
24277974
NACRES:
NA.32

Key Documents

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Product Name

Dextrorphan tartrate, powder

description

Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

Quality Level

200

form

powder

drug control

Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

color

white

solubility

H2O: >10 mg/mL

SMILES string

O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34

InChI

1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m10/s1

InChI key

RWTWIZDKEIWLKQ-FEBOIHDFSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

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Application

Dextrorphan tartrate has been used to study its effects on blood glucose levels by targeting pancreatic islets.

Biochem/physiol Actions

Dextrorphan is a noncompetitive NMDA glutamate receptor antagonist that attenuates glutamate neurotoxicity in cortical cell cultures.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BGBC4073
BGBC2001
112M4708V
070M4616
010M4618

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A I Faden et al.
Science (New York, N.Y.), 244(4906), 798-800 (1989-05-19)
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with

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