C5988
Anti-Calcium Channel (β1 subunit) antibody produced in rabbit
~1 mg/mL, fractionated antiserum, buffered aqueous solution
Synonym(s):
Anti-Voltage-dependent L-type calcium channel, β1 subunit
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
fractionated antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
western blot: 5-10 μg/mL using rat brain tissue lysate
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CACNB1(782)
mouse ... Cacnb1(12295)
rat ... Cacnb1(50688)
General description
The gene CACNB1 (Calcium channel voltage-dependent subunit β 1) is mapped to human chromosome 17q11.2-q22.
Immunogen
synthetic peptide derived from the rat β1 calcium channel conjugated to KLH.
Application
Anti-Calcium Channel (β1 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10 μg/mL using rat brain tissue lysate
Biochem/physiol Actions
The CACNB1 (Calcium channel voltage-dependent subunit β 1) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. CACNB1 is a target of miRNA-328. In mouse model, CACNB1 is involved in gene expression in muscle progenitor cells and regulates skeletal muscle mass during embryonic development by suppressing myogenin.
Physical form
Solution in phosphate buffered saline containing 0.08% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
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Related Content
Jackson Taylor et al.
The Journal of cell biology, 205(6), 829-846 (2014-06-18)
Voltage-gated calcium channel (Cav) β subunits are auxiliary subunits to Cavs. Recent reports show Cavβ subunits may enter the nucleus and suggest a role in transcriptional regulation, but the physiological relevance of this localization remains unclear. We sought to define
Yanjie Lu et al.
Circulation, 122(23), 2378-2387 (2010-11-26)
A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca(2+) current and shortening of the action potential duration. The possibility that microRNAs (miRNAs) may be involved in this process
R G Gregg et al.
Genomics, 15(1), 185-187 (1993-01-01)
A human clone containing a portion of the gene encoding several isoforms of the beta 1 subunit of voltage-dependent calcium channels was isolated and partially sequenced. The gene was mapped to chromosome 17 using the polymerase chain reaction with oligonucleotides
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C5988-100UG | 04061838070548 |