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C4032

Casein, Dephosphorylated from bovine milk

lyophilized powder

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About This Item

CAS Number:
9000-71-9
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00130736
Form:
lyophilized powder
Assay:
≥85% (biuret)
Biological source:
bovine milk
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biological source

bovine milk

Quality Level

200

assay

≥85% (biuret)

form

lyophilized powder

UniProt accession no.

P02666, P02668

storage temp.

2-8°C

SMILES string

[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

Gene Information

bovine ... CSN2(281099), CSN3(281728)

General description

Dephosphorylated casein is prepared by the action of potato acid phosphatase. It displays improved solubility and less foaming.

Application

Casein, Dephosphorylated from bovine milk has been used as a substrate in in vitro kinase assays of Arabidopsis thaliana GSK3/Shaggy like kinase, casein kinase II and NIMA (never in mitosis A)-related kinase 2 (Nek2).

Biochem/physiol Actions

Clusters of phosphoserine in casein chelate iron and reduce its bioavailability. Partial enzymatic digestion of casein unmasks phosphorylated residues to alkaline phosphatase, permitting dephosphorylation and increasing the bioavailability of iron.
Dephosphorylated casein lacks a net negative charge and is less sensitive to calcium. It is useful in food industry.

Analysis Note

At least 70% dephosphorylated.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
067K7400
124K7440
119F9585
101H9535
055H9500

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High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase.
Hirota T., et al.
PLoS Biology, 8 (2010)
Casein, Dephosphorylated, has been used in studies of modulators of circadian clocks. It has been shown that several molecules can inhibit casein kinase which results in the lenghthening of these clocks.
Chen, Z., et al.
Proceedings of the National Academy of Sciences of the USA (2011)
Marie Lawson et al.
European journal of medicinal chemistry, 123, 105-114 (2016-07-31)
We report here the synthesis, the biological evaluation and the molecular modeling studies of new imidazo[1,2-a]pyridines derivatives designed as potent kinase inhibitors. This collection was obtained from 2-aminopyridines and 2-bromoacetophenone which afforded final compound in only one step. The bioactivity
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Global Trade Item Number

SKUGTIN
C4032-100MG04061833487112