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C1355

Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate

≥90%

Synonym(s):

Z-LEHD-FMK, Z-LE(OMe)HD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C32H43FN6O10 · xC2HF3O2 · yH2O
CAS Number:
210345-04-3
Molecular Weight:
690.72 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329774878
MDL number:
MFCD01862609
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assay

≥90%

form

film

storage condition

desiccated

color

colorless to light brown

solubility

DMSO: 10 mg/mL, clear

shipped in

dry ice

storage temp.

−20°C

SMILES string

COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

InChI

1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)/t22-,23-,24-,25-/m0/s1

InChI key

YXRKBEPGVHOXSV-QORCZRPOSA-N

Application

A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
057K1834
056K1373
016K1279
095K1206
035K1287

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Maegan L Askew et al.
Frontiers in systems neuroscience, 9, 91-91 (2015-07-01)
This study used immunohistochemical methods to investigate the possibility that hypothalamic neurons that contain 11-β-hydroxysteroid dehydrogenase type 2 (HSD2) are involved in the control of feeding by rats via neuroanatomical associations with the α subtype of estrogen receptor (ERα), catecholamines
Melissa García-Caballero et al.
Frontiers in pharmacology, 8, 802-802 (2017-11-23)
Evasion of apoptosis is a hallmark of cancer especially relevant in the development and the appearance of leukemia drug resistance mechanisms. The development of new drugs that could trigger apoptosis in aggressive hematological malignancies, such as AML and CML, may
Zheng-Zhi Zou et al.
Oncotarget, 8(14), 22414-22432 (2015-10-16)
Here, we showed the antibiotic salinomycin (SAL) combined with GEF exerted synergistic cytotoxicity effects in colorectal cancer cells irrespective of their EGFR and KRAS status, with a relatively low toxicity to normal cells. Additionally, combination of the two drugs overcame
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Global Trade Item Number

SKUGTIN
C1355-1MG04061826674000