B3805
Anti-Bone Morphogenetic Protein 5 antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-BMP-5
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
immunohistochemistry (frozen sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL
UniProt accession no.
application(s)
research pathology
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BMP5(653)
Immunogen
recombinant human BMP-5, expressed in NSO cells.
Biochem/physiol Actions
Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP5 is required for the development and fine tuning of the skeletal morphology.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Steven Pregizer et al.
Cytokine & growth factor reviews, 20(5-6), 509-515 (2009-11-11)
Much evidence suggests that "developmental regulator" genes, like those encoding transcription factors and signaling molecules, are typically controlled by many modular, tissue-specific cis-regulatory elements that function during embryogenesis. These elements are often far from gene coding regions and promoters. Bone
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various
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