AV35735
Anti-PIAS2 (AB2) antibody produced in rabbit
IgG fraction of antiserum
Synonym(s):
Anti-Protein inhibitor of activated STAT, 2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
68 kDa
species reactivity
mouse, human, dog, horse, rabbit
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PIAS2(9063)
Immunogen
Synthetic peptide directed towards the C terminal region of human PIAS2
Biochem/physiol Actions
Protein inhibitor of activated STAT (PIAS) family of proteins mediates the sumoylation of proteins by acting as SUMO E3 ligases. Some important proteins that are sumoylated by PIAS are p53, c-Jun and the androgen receptor.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: FLDSLTSPLTASSTSVTTTSSHESSTHVSSSSSRSETGVITSSGSNIPDI
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Brendan Burn et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 240(9), 2120-2126 (2011-07-23)
Originally identified as cytokine inhibitors, protein inhibitors of activated STAT (PIAS) are shown to regulate activities of a plethora of proteins and influence diverse processes such as immune response, cancer formation, and cell cycle progression. However, the roles of PIAS
Jocelyn Widagdo et al.
PloS one, 7(11), e49283-e49283 (2012-11-13)
GTF2IRD1 is one of the genes implicated in Williams-Beuren syndrome, a disease caused by haploinsufficiency of certain dosage-sensitive genes within a hemizygous microdeletion of chromosome 7. GTF2IRD1 is a prime candidate for some of the major features of the disease
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