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A9187

Sigma-Aldrich

Adenosine 5′-triphosphate magnesium salt

≥95%, bacterial, powder

Synonym(s):

ATP, ATP magnesium salt

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About This Item

Empirical Formula (Hill Notation):
C10H16N5O13P3 · xMg2+
CAS Number:
74804-12-9
Molecular Weight:
507.18 (free acid basis)
MDL number:
MFCD00084767
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24891422
NACRES:
NA.51

Key Documents

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Product Name

Adenosine 5′-triphosphate magnesium salt, ≥95%, bacterial

biological source

bacterial

Quality Level

200

assay

≥95%

form

powder

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

[Mg].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H16N5O13P3.Mg.2H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;

InChI key

CPGAIACWYFBIFN-UHFFFAOYSA-N

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Application

Adenosine 5′-triphosphate magnesium salt has been used:
  • as a supplement in intracellular medium for Ca2+ retention assay and fluorescence wide field imaging analysis
  • as a component in potassium methane sulfonate-based internal solution for in vitro electrophysiology of cortical neurons
  • as a component in action potential intracellular solution

Biochem/physiol Actions

Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H371

Hazard Classifications

STOT SE 2

target_organs

Eyes,Central nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000283362
0000283360
0000283364
0000297531
0000283362

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Hyun Jong Kim et al.
European journal of pharmacology, 791, 686-695 (2016-10-30)
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De La Fuente S, et al.
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Archives of toxicology, 92(9), 2875-2884 (2018-08-08)
Transporter-mediated drug-drug interactions (DDI) may induce adverse clinical events. As drugs of abuse (DOA) are marketed without preclinical safety studies, only very limited information about interplay with membrane transporters are available. Therefore, 13 DOA of various classes were tested for
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
Fenske S, et al.
Nature Protocols, 11(1), 61-61 (2016)
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Girasole AE, et al.
Neuron, 97(4), 787-795 (2018)
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