A5285
Adenosine 5′-diphosphate monopotassium salt dihydrate
bacterial, ≥95%, P2Y receptor agonist, powder
Synonym(s):
Adenosine 5′-Diphosphate Potassium Salt, ADP
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About This Item
Empirical Formula (Hill Notation):
C10H14KN5O10P2 · 2H2O
CAS Number:
Molecular Weight:
501.32
MDL number:
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.77
Product Name
Adenosine 5′-diphosphate monopotassium salt dihydrate, bacterial, ≥95%, powder
biological source
bacterial
Quality Level
assay
≥95%
form
powder
storage temp.
−20°C
SMILES string
[O-]P(OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N2C3=C(N=C2)C(N)=NC=N3)(O)=O)(O)=O.[K+]
InChI
1S/C10H15N5O10P2.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
InChI key
ZNCWUOPIJTUALR-MCDZGGTQSA-M
Gene Information
human ... HSP90AA1(3320), P2RY1(5028)
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General description
Adenosine diphosphate (ADP) is a crucial component for energy flow in living organisms. Its structure consists of a sugar backbone connected to adenine and two phosphate groups attached to the fifth carbon atom of the ribose sugar. ADP serves a precursor for ATP biosynthesis. ADP acts as a weak platelet agonist, specifically targeting the P2Y receptor. However, ADP plays a vital role in platelet function by enhancing the effects of other platelet agonists and promoting the stability of platelet aggregates when released from platelet dense granules.
Application
Adenosine 5′-diphosphate has been used to study the release, neuronal effects, and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. Adenosine 5′-diphosphate has also been used to compare prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome.
Adenosine 5′-diphosphate monopotassium salt dihydrate (ADP) has been used:
- in titration to determine complex I-supported respiration in permeabilized muscle fibers
- in titrations to determine ADP-stimulated respiratory kinetics
- in the preparation of ADP solution for measuring mitochondrial respiration
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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James E Tcheng et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 12(2), 83-91 (2012-02-10)
Antithrombotic therapy is imperative in the management of patients presenting with an acute coronary syndrome (ACS). The combination of antiplatelet therapy in conjunction with antithrombotic therapy has become the standard of care in improving the morbidity and mortality of patients
Correlation between Labeling Yield and Surface Accessibility in Covalent Labeling Mass Spectrometry.
Daniel S Ziemianowicz et al.
Journal of the American Society for Mass Spectrometry, 31(2), 207-216 (2020-02-08)
The functional properties of a protein are strongly influenced by its topography, or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topographical data through the measurement of surface
Leonie Durnin et al.
The European journal of neuroscience, 35(3), 423-435 (2012-01-27)
Recent evidence supports an emerging role of β-nicotinamide adenine dinucleotide (β-NAD(+) ) as a novel neurotransmitter and neuromodulator in the peripheral nervous system -β-NAD(+) is released in nerve-smooth muscle preparations and adrenal chromaffin cells in a manner characteristic of a
Meera Kumar et al.
SLAS discovery : advancing life sciences R & D, 25(3), 320-326 (2019-12-24)
Production of adenosine in the extracellular tumor microenvironment elicits strong immunosuppression and is associated with tumor progression. Thus, targeting adenosine-generating ectonucleotidases is a potential strategy to stimulate and prolong antitumor immunity. Because the reaction products of ectonucleotidases differ by a
Theresa H Tam et al.
The Journal of biological chemistry, 295(15), 4902-4911 (2020-03-07)
Obesity and elevation of circulating free fatty acids are associated with an accumulation and proinflammatory polarization of macrophages within metabolically active tissues, such as adipose tissue, muscle, liver, and pancreas. Beyond macrophages, neutrophils also accumulate in adipose and muscle tissues
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