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A0231

Sigma-Aldrich

AS 604850

≥98% (HPLC), solid

Synonym(s):

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI3Kγ inhibitor

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About This Item

Empirical Formula (Hill Notation):
C11H5F2NO4S
CAS Number:
648449-76-7
Molecular Weight:
285.22
MDL number:
MFCD19705528
UNSPSC Code:
12352200
PubChem Substance ID:
24724381
NACRES:
NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >10 mg/mL
H2O: <2 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

FC1(F)Oc2ccc(cc2O1)\C=C3/SC(=O)NC3=O

InChI

1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-

InChI key

SRLVNYDXMUGOFI-YWEYNIOJSA-N

Related Categories

Biochem/physiol Actions

AS 604850 is a selective PI3Kγ inhibitor

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
106K4618V
106K46183
106K46182
106K46181
106K4618

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Montserrat Camps et al.
Nature medicine, 11(9), 936-943 (2005-08-30)
Phosphoinositide 3-kinases (PI3K) have long been considered promising drug targets for the treatment of inflammatory and autoimmune disorders as well as cancer and cardiovascular diseases. But the lack of specificity, isoform selectivity and poor biopharmaceutical profile of PI3K inhibitors have
Hon Yan K Yip et al.
Molecular cell, 80(2), 279-295 (2020-10-17)
The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition of PI3K pathway is well characterized, the biological relevance of PTEN protein-phosphatase activity

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Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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