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MilliporeSigma

81255

Sigma-Aldrich

Poly(ethylene glycol)

greener alternative

BioUltra, 6,000

Synonym(s):

Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
MDL number:
MFCD00081839
UNSPSC Code:
12352104
PubChem Substance ID:
24887715
NACRES:
NA.26

Key Documents

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Quality Level

200

product line

BioUltra

form

solid

mol wt

Mr 5000-7000

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Safer Solvents and Auxiliaries
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impurities

insoluble matter, passes filter test
≤20 mg/kg peroxides (as H2O2)

pH

5.5-7.0 (25 °C, 50 mg/mL in H2O)

solubility

H2O: 50 mg/mL at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

50 mg/mL in H2O

UV absorption

λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.10

greener alternative category

Aligned

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Poly(ethylene glycol) (PEG) is a non-ionic hydrophilic polymer and is available in different molecular weights. It helps in the purification and crystal growth of proteins and nucleic acids. PEG and dextran together result in aqueous polymer two phase system, which is required for the purification of biological materials. PEG also interacts with cell membrane, thereby allowing cell fusion.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Application

Poly(ethylene glycol) has been used for stress (dehydration) treatment in seedlings of Galegae orientalis. It has been used for the preparation of aqueous two-phase system to study protein diffusion across the interface.

Other Notes

Fractional precipitation of proteins; Protoplast fusion; In virus purification; Electroblotting of proteins on agarose gel containing PEG and antibodies

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG7561
BCCG0243
BCCF8516
BCCF5449
BCCD9233

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Protein diffusion across the interface in aqueous two-phase systems.
Munchow G, et al.
Langmuir, 24, 8547-8553 (2008)
R F Atmeh et al.
Electrophoresis, 14(1-2), 69-72 (1993-01-01)
A method is described for electroblotting of proteins, separated by gradient polyacrylamide gel electrophoresis, onto an agarose gel matrix containing specific antibodies. Three proteins of different molecular weight, including human albumin, isolated and in plasma, human plasma transferrin and C3
Rapid bacteriophage sedimentation in the presence of polyethylene glycol and its application to large-scale virus purification.
K R Yamamoto et al.
Virology, 40(3), 734-744 (1970-03-01)
José A Manso et al.
Structure (London, England : 1993), 27(6), 952-964 (2019-04-23)
Mechanical stability of epithelia requires firm attachment to the basement membrane via hemidesmosomes. Dysfunction of hemidesmosomal proteins causes severe skin-blistering diseases. Two plakins, plectin and BP230 (BPAG1e), link the integrin α6β4 to intermediate filaments in epidermal hemidesmosomes. Here, we show
J.B. Power et al.
Methods in Enzymology, 118, 578-578 (1986)
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