Skip to Content
MilliporeSigma

Key Documents

View All Documentation

PHR1666

Diethyl Ether

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Diethyl ether, Ether, Ethyl ether

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
(CH3CH2)2O
CAS Number:
60-29-7
Molecular Weight:
74.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823542
EC Number:
200-467-2
Beilstein/REAXYS Number:
1696894
MDL number:
MFCD00011646
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

vapor density

2.6 (vs air)

CofA

current certificate can be downloaded

autoignition temp.

320 °F

quality

pharmaceutical secondary standard

expl. lim.

36.5 %

packaging

pkg of 3 × 1.2 mL

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.3530 (lit.)

bp

34.6 °C (lit.)

mp

−116 °C (lit.)

density

0.706 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCOCC

InChI

1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3

InChI key

RTZKZFJDLAIYFH-UHFFFAOYSA-N

General description

Diethyl ether is a non-polar volatile organic solvent, commonly used as an extraction solvent in liquid-liquid extraction for separation of post reaction residues from synthetic products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Diethyl ether may be used as a solvent reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0145 in the slot below. This is an example certificate only and may not be the lot that you receive.

Still not finding the right product?

Explore all of our products under Diethyl Ether

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 1 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH019,EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-40.0 °F - closed cup

flash_point_c

-40 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Residual solvent testing: a review of gas-chromatographic and alternative techniques
B'Hymer C
Pharmaceutical Research, 20(3), 337-344 (2003)
Determination of residual solvent levels in bulk pharmaceuticals by capillary gas chromatography
Smith ID and Waters DG
Analyst, 116(12), 1327-1331 (1991)
Organic solvents in the pharmaceutical industry
Grodowska K and Parczewski A
Acta Poloniae Pharmaceutica, 67(1), 3-12 (2010)

Global Trade Item Number

SKUGTIN
PHR1666-3X1.2ML04061837884221