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MilliporeSigma

PHR1117

Supelco

Butylated Hydroxytoluene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Linear Formula:
[(CH3)3C]2C6H2(CH3)OH
CAS Number:
128-37-0
Molecular Weight:
220.35
Beilstein/REAXYS Number:
1911640
EC Number:
204-881-4
MDL number:
MFCD00011644
UNSPSC Code:
41116107
PubChem Substance ID:
329823138
E Number:
E321
NACRES:
NA.24

Key Documents

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to Ph. Eur. B1215000
traceable to USP 1092708

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

API family

butylated hydroxytoluene

CofA

current certificate can be downloaded

autoignition temp.

878 °F

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Butylated hydroxytoluene (BHT) is a phenolic antioxidant used as a food additive. It is frequently added to dried cereals, cooking oils and animal foods. BHT is also known to enhance the stability of pharmaceuticals, fat-soluble vitamins and cosmetics .

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3695 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

260.6 °F - open cup

flash_point_c

127 °C - open cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reactivity of butylated hydroxytoluene.
Lambert CR, et al.
Free Radical Biology & Medicine, 21(3), 395-400 (1996)
Deliang Guo et al.
Science signaling, 2(101), ra82-ra82 (2009-12-17)
Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma, their clinical relevance is poorly understood. Studies of tumors from patients treated
Hiroya Okamoto et al.
Experimental dermatology, 21 Suppl 1, 5-7 (2012-06-01)
Pt nanoparticle is a strong reductant and has been used as an antioxidant in cosmetics and medicine. It was reported to have catalase-like activity, which converts hydrogen peroxide to water and oxygen. However, in this study, freshly prepared Pt nanoparticle
A M Malkinson
Environmental mutagenesis, 5(3), 353-362 (1983-01-01)
Although the average American's daily consumption of BHT can be measured in milligrams, there are numerous reports that BHT causes organ damage in laboratory animals. Only a few genotoxic effects of BHT have been reported, however, including mutagenicity in the
Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).
H Witschi et al.
Pharmacology & therapeutics, 42(1), 89-113 (1989-01-01)
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