E2150000
Ethosuximide
European Pharmacopoeia (EP) Reference Standard
Synonym(s):
2-Ethyl-2-methylsuccinimide
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About This Item
Empirical Formula (Hill Notation):
C7H11NO2
CAS Number:
Molecular Weight:
141.17
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
ethosuximide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
O=C1NC(CC1(C)CC)=O
InChI
1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI key
HAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Information
human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Ethosuximide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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J S Millership et al.
European journal of drug metabolism and pharmacokinetics, 18(4), 349-353 (1993-10-01)
The metabolism of the antiepileptic drug ethosuximide (3-ethyl-3-methylpyrollidine-2,5-dione) (I) in animals and humans is reviewed. Chiral aspects of the metabolism of ethosuximide are discussed. Clarification of the precise nature of the hydroxymetabolites of ethosuximide is presented.
[Ethosuximide].
M Ichiba et al.
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 1, 915-917 (1995-02-01)
Sloka S Iyengar et al.
Experimental neurology, 264, 135-149 (2014-12-06)
Adult neurogenesis, the generation of new neurons in the adult brain, occurs in the hippocampal dentate gyrus (DG) and the olfactory bulb (OB) of all mammals, but the functions of these new neurons are not entirely clear. Originally, adult-born neurons
Ewa B Posner et al.
Seizure, 14(2), 117-122 (2005-02-08)
To evaluate the role of ethosuximide, sodium valproate and lamotrigine in children and adolescents with typical absence seizures (AS). A systematic review of randomized controlled trials that included children or adolescents with typical absence seizures who received treatment with ethosuximide
M Zafer Gören et al.
CNS drug reviews, 13(2), 224-239 (2007-07-14)
Ethosuximide, 2-ethyl-2-methylsuccinimide, has been used extensively for "petit mal" seizures and it is a valuable agent in studies of absence epilepsy. In the treatment of epilepsy, ethosuximide has a narrow therapeutic profile. It is the drug of choice in the
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