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C0750

Caffeine

Name: Caffeine
Brand: SIAL

powder, ReagentPlus^®

Synonym(s):

Guaranine, Methyltheobromine, 1,3,7-Trimethylxanthine

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₀N₄O₂

CAS Number:

58-08-2

Molecular Weight:

194.19

UNSPSC Code:

12352210

NACRES:

NA.21

PubChem Substance ID:

24277682

EC Number:

200-362-1

Beilstein/REAXYS Number:

17705

MDL number:

MFCD00005758

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Properties

Quality Level

200

product line

ReagentPlus^®

form

powder

mp

234-236.5 °C (lit.)

solubility

H₂O: 15 mg/mL

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Description

General description

Caffeine is a widely ingested pharmacologically active substance and is known to affect the central nervous system. It belongs to the class of methylxanthines. It is a naturally occurring alkaloid found in coffee, cocoa and other plants. Caffeine might be associated with osteoporosis, cardiovascular risk, arrhythmia and gastrointestinal disturbances. Caffeine is used to treat orthostatic hypotension, bronchopulmonary dysplasia and apnea of prematurity (AOP).

Application

Caffeine has been used:

to study its impact on the fluorescence of Petunia nuclei
as a stimulant to induce c-fos expression in rodents
as a component of defined media for the development of bovine oocytes in vitro

Biochem/physiol Actions

Caffeine is a natural stimulant that is most commonly found in coffee, tea and various other drinks. It is known for its effect on the central nervous system. It is also associated with insomnia, increased heart rate, digestive issues, creating anxiety and jitteriness. Caffeine is also associated with withdrawal symptoms like headaches, fatigue, irritability.

Features and Benefits

High purity product that can be used readily for HPLC applications along with other research applications.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Keep tightly sealed.

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Explore all of our products under Caffeine

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Protocols

Protocol for In-vitro Permeation Testing Using Strat-M^® Membranes

Strat-M^® synthetic membrane mimics the human skin for In-vitro permeation testing (IVPT) of topical and transdermal formulations

A simple method for immunohistochemical staining of zebrafish brain sections for c-fos protein expression

Chatterjee D, et al.

Zebrafish, 12(6), 414-420 (2015)

Effects of caffeine and chlorogenic acid on propidium iodide accessibility to DNA: consequences on genome size evaluation in coffee tree

Noirot M, et al.

Annals of Botany, 92(2), 259-264 (2003)

Effects of caffeine on human health

Nawrot P, et al.

Food Additives and Contaminants, 20(1), 1-30 (2003)

View All Related Papers

Global Trade Item Number

SKU	GTIN
C0750-1KG	04061833451564
C0750-500G	04061835543137
C0750-5G	04061835543144
C0750-100G	04061835543120

Key Documents

Caffeine

powder, ReagentPlus^®

Select a Size

About This Item

Quality Level

product line

form

mp

solubility

SMILES string

InChI

InChI key

Gene Information

General description

Application

Biochem/physiol Actions

Features and Benefits

Legal Information

Disclaimer

Still not finding the right product?

Safety Information

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Protocols and Articles

Protocols

Peer Reviewed Papers

Global Trade Item Number

Key Documents

Caffeine

powder, ReagentPlus®

Select a Size

About This Item

Quality Level

product line

form

mp

solubility

SMILES string

InChI

InChI key

Gene Information

General description

Application

Biochem/physiol Actions

Features and Benefits

Legal Information

Disclaimer

Still not finding the right product?

Safety Information

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Protocols and Articles

Protocols

Peer Reviewed Papers

Global Trade Item Number

powder, ReagentPlus^®