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39405

4-(Dimethylamino)pyridine

purum, ≥98.0% (NT)

Synonym(s):

N,N-Dimethylpyridin-4-amine, DMAP

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About This Item

Empirical Formula (Hill Notation):
C7H10N2
CAS Number:
Molecular Weight:
122.17
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
214-353-5
Beilstein/REAXYS Number:
110354
MDL number:
Assay:
≥98.0% (NT)
Form:
crystals, pellets
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grade

purum

Quality Level

assay

≥98.0% (NT)

form

crystals, pellets

mp

108-110 °C (lit.), 111-114 °C

solubility

methanol: 0.1 g/mL, clear, colorless to almost colorless

functional group

amine

SMILES string

CN(C)c1ccncc1

InChI

1S/C7H10N2/c1-9(2)7-3-5-8-6-4-7/h3-6H,1-2H3

InChI key

VHYFNPMBLIVWCW-UHFFFAOYSA-N

General description

4-(Dimethylamino)pyridine is generally employed as a catalyst in the acylation of amines, alcohols, enolates, and phenols. It can also be used in the esterification of carboxylic acids. It is known to exhibit good catalytic activity in non-polar solvents.

Application

A highly efficient catalyst for acylation reactions
4-(Dimethylamino)pyridine can be used:
  • As a capping agent in the preparation of water-soluble gold nanoparticles.
  • As an initiator in the polymerization of epoxy monomers.
  • As an auxiliary reagent in the electroless preparation of gold nanotubes applicable in catalysis.
  • As a catalyst in the preparation of γ- and δ-lactones via iodolactonization of γ,δ-unsaturated carboxylic acids.

Other Notes

Hypernucleophilic acylation catalyst.


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Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 1

target_organs

Nervous system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

255.2 °F

flash_point_c

124 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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A. Hassner
Tetrahedron, 34, 2069-2069 (1978)
E.F. Scriben
Chemical Society Reviews, 13, 129-129 (1983)
Hoefle, G., et al.
Angewandte Chemie (International Edition in English), 90, 602-602 (1978)



Global Trade Item Number

SKUGTIN
39405-10G04061831982190
39405-1KG04061826714614
39405-250G04061831982206
39405-50G04061831982213