Key Documents

View All Documentation

271004

Acetonitrile

Name: Acetonitrile
Brand: SIAL

99.8%, anhydrous, suitable for solid phase extraction (SPE)

Synonym(s):

Methyl cyanide, Anhydrous ACN, Dry MeCN

Select a Size

Change View

About This Item

Linear Formula:

CH₃CN

CAS Number:

75-05-8

Molecular Weight:

41.05

NACRES:

NA.21

PubChem Substance ID:

57648217

eCl@ss:

39031501

UNSPSC Code:

12191502

EC Number:

200-835-2

MDL number:

MFCD00001878

Beilstein/REAXYS Number:

741857

Assay:

99.8%

Grade:

anhydrous

Technique(s):

solid phase extraction (SPE): suitable

Bp:

81-82 °C (lit.)

Vapor pressure:

72.8 mmHg ( 20 °C)

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Acetonitrile, anhydrous, 99.8%

grade

anhydrous

Quality Level

200

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

assay

99.8%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

technique(s)

solid phase extraction (SPE): suitable

impurities

<0.001% water, <0.005% water (100 mL pkg)

evapn. residue

<0.0005%

color

colorless

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

solubility

water: soluble (completely)

density

0.786 g/mL at 25 °C (lit.)

format

neat

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

Description

General description

Acetonitrile, an aliphatic nitrile, is widely used as an organic solvent and intermediate in organic syntheses. It is transparent to UV-visible light, which makes it highly applicable in spectrophotometric and fluorimetric techniques. MeCN is utilized as a mobile phase component in many chromatographic techniques, due to its low viscosity, high elution strength and miscibility in water. It also plays a major role as an extractant medium in liquid-liquid extraction, solid-phase extraction or microextraction.

Application

Acetonitrile may be used as a solvent to prepare:

1,2-Azidoalcohols and 1,2-azidoamines via cerium(III) chloride assisted ring opening of epoxides and aziridines by sodium azide.
Cyano-bearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst.

It may also be used as a reactant to synthesize:

Bis (diphenylphosphino) acetonitrile by reacting with n-butyllithium and then with chlorodiphenylphosphine.
β-Acetamido ketones via coupling reaction with ketones or ketoesters and aldehydes in the presence of cobalt(II) chloride.

Packaging

View returnable container options.

Still not finding the right product?

Explore all of our products under Acetonitrile

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H302 + H312 + H332,H319

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Solvent Miscibility Table

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

Tabla de miscibilidad de disolventes

Se dice que las sustancias son miscibles entre sí si se disuelven hasta formar una disolución uniforme. Marque o descargue nuestra tabla de miscibilidad para los disolventes comunes del laboratorio.

Bis (diphenylphosphino) acetonitrile: Synthesis, ligand properties and application in catalytic carbon?carbon coupling

Braun L, et al.

Dalton Transactions, 14, 1409-1415 (2007)

Cobalt-catalysed three-component coupling involving ketones or ketoesters, aldehydes and acetonitrile: a novel one-pot synthesis of ?-acetamido ketones

Madhavaa Reddy M.

Journal of the Chemical Society. Chemical Communications, 6, 713-714 (1994)

Eagleson M.

Concise Encyclopedia Chemistry, 56-56 (1994)

View All Related Papers

Global Trade Item Number

SKU	GTIN
271004-100ML	04061837532078
271004-18L-P1	04061838151803
271004-200L	04061838151810
271004-200L-P2-B	04061838151841
271004-20L-P2	04061838161376
271004-2L-KR	04065268544679
271004-4X2L	04061826143582
271004-4X2L-KR	04065268892565
271004-CH-200LP1KO	04061841232285
271004-12X100ML	04061837532085
271004-1L	04061826143575
271004-200L-P1	04061838151827
271004-200L-P2	04061838151834
271004-2L	04061837532108
271004-50L-P2	04061838161383
271004-56L	04061836608644
271004-6X1L	04061837532115
271004-AR-200L-P1	04065269106890
271004-OD-200L-P2	04065269106906