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MilliporeSigma

235989

Sigma-Aldrich

Brij® L4

average Mn ~362

Synonym(s):

Polyethylene glycol dodecyl ether, Polyoxyethylene (4) lauryl ether

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About This Item

Linear Formula:
(C20H42O5)n
CAS Number:
9002-92-0
MDL number:
MFCD00043063
UNSPSC Code:
12161900
PubChem Substance ID:
24854130
NACRES:
NA.21

Key Documents

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description

non-ionic

Quality Level

200

form

solid or liquid

mol wt

average Mn ~362

impurities

≤1% Water

refractive index

n20/D 1.451 (lit.)

mp

48 °C

solubility

water: insoluble

density

0.95 g/mL at 25 °C (lit.)

HLB

9

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCO

InChI

1S/C20H42O5/c1-2-3-4-5-6-7-8-9-10-11-13-22-15-17-24-19-20-25-18-16-23-14-12-21/h21H,2-20H2,1H3

InChI key

WPMWEFXCIYCJSA-UHFFFAOYSA-N

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General description

Brij® L4 is a non-ionic surfactant. It comprises an alkyl (C12) tail attached to an oxyethylene headgroup.

Application

Brij® L4 has been used:
  • as a surfactant for the synthesis of copper(I) oxide (Cu2O) spherical nanoparticles using a microemulsion technique
  • as a non-ionic surfactant for preparing reverse micelles to synthesize Pt3Co alloy nanoparticles
  • as a surfactant to enhance the efficiency of interfacial coupling of hydrophobic materials and to make hydrogel

Biochem/physiol Actions

Brij® L4 exhibits amphiphilic properties. Brij L4 contains hydrophobic and hydrophilic regions that can form micelles and disperse hydrophobic drugs into the core of micelles. This in turn enhances drug solubility. Brij L4 also elicits a strong inhibitory effect against breast cancer resistance protein (BCRP) mediated drug efflux. It inhibits Taq adsorption better when compared to other commonly used surfactants. Brij L4 supports droplet polymerase chain reaction (PCR) in picoliter reaction volumes at standard Taq concentrations.

Legal Information

Brij is a registered trademark of Croda International PLC

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ7698
MKCL6849
MKCK4613
MKCH6859
MKCD2308

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Darío Morais et al.
Rhinology, 50(1), 80-86 (2012-04-04)
Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the
N Shadid et al.
The British journal of surgery, 99(8), 1062-1070 (2012-05-26)
New minimally invasive treatment modalities, such as ultrasound-guided foam sclerotherapy (UGFS), are becoming more popular. In a multicentre randomized controlled non-inferiority trial, the effectiveness and costs of UGFS and surgery for treatment of the incompetent great saphenous vein (GSV) were
B McAree et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 43(6), 721-725 (2012-04-18)
To compare the half-life of STD and polidocanol air-based foams and the damage they inflict upon human great saphenous vein in an in-vitro model. The time for the volume of 3% STD and polidocanol foams to reduce by 10% (T(90))
L Lund et al.
The Journal of urology, 191(5), 1347-1350 (2013-11-23)
We evaluate whether aspiration and sclerosing of hydrocele testis is an effective treatment. Men with symptomatic hydrocele testis were included in this prospective, double-blind, randomized study with polidocanol and placebo. Patients were randomized to active treatment or placebo at the
Alessandro Frullini et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 38(5), 741-747 (2012-05-01)
Foam sclerotherapy has been proven to be a safe and effective treatment for superficial venous insufficiency, but transient visual and neurologic disturbances continue to be reported. These side effects have been theorized to be related to the presence of air
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