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MilliporeSigma

15238

Supelco

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane

derivatization grade (GC derivatization), LiChropur™, contains 1% TMCS, 99% (excluding TMCS)

Synonym(s):

Silylating mixture V, BSTFA + TMCS

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About This Item

Linear Formula:
CF3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
25561-30-2
Molecular Weight:
257.40
Beilstein/REAXYS Number:
2050024
MDL number:
MFCD00008269
UNSPSC Code:
41116105
PubChem Substance ID:
329750793
NACRES:
NA.22

Key Documents

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grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥98.5% (excluding chlorotrimethylsilane, GC)
99% (excluding TMCS)

form

liquid

quality

LiChropur™
contains 1% TMCS

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.384 (lit.)

bp

45-50 °C/14 mmHg (lit.)

density

0.97 g/mL (lit.)

SMILES string

C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F

InChI

1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+

InChI key

XCOBLONWWXQEBS-KPKJPENVSA-N

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Application

Learn more in the Product Information

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Other Notes

Silylating mixture used for the silylation of various compounds
The position of the silyl groups has not been unequivocally established. It has been referred to as both N,N and N,O.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

44.1 °F - closed cup

flash_point_c

6.7 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1594
BCCG9552
BCCG9553
BCCG9302
BCCD2584

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W.M. Hammargren et al.
Analytica Chimica Acta, 247, 201-201 (1991)
W. Greenway et al.
Journal of Chromatography A, 519, 145-145 (1990)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Metabolism of arachidonate through NADPH-dependent oxygenase of renal cortex.
Proceedings of the National Academy of Sciences of the USA, 78 (12), 7375-7378 (1981)
DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine.
Helbock H
Proceedings of the National Academy of Sciences of the USA, 95 (1), 288-293 (1998)
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Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

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