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19-4497

Metronidazole

Name: Metronidazole
Brand: SAJ

SAJ first grade, ≥99.0%

Synonym(s):

2-Methyl-5-nitroimidazole-1-ethanol

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About This Item

Empirical Formula (Hill Notation):

C₆H₉N₃O₃

CAS Number:

443-48-1

Molecular Weight:

171.15

EC Number:

207-136-1

UNSPSC Code:

12352005

PubChem Substance ID:

329751879

Beilstein/REAXYS Number:

611683

MDL number:

MFCD00009750

Assay:

≥99.0%

Grade:

SAJ first grade

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Properties

grade

SAJ first grade

assay

≥99.0%

form

solid

availability

available only in Japan

dilution

(for analytical testing)

mp

159-161 °C (lit.)

antibiotic activity spectrum

Gram-negative bacteria, parasites

mode of action

DNA synthesis | interferes

SMILES string

CC1=NC=C([N+]([O-])=O)N1CCO

InChI

1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

InChI key

VAOCPAMSLUNLGC-UHFFFAOYSA-N

Description

General description

Chemical structure: imidazole

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pictograms

GHS08

signalword

Danger

hcodes

H340,H350,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 1B - Muta. 1B - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Efficacy of the antimicrobial peptide TP4 against Helicobacter pylori infection: in vitro membrane perturbation via micellization and in vivo suppression of host immune responses in a mouse model.

Jayaram Lakshmaiah Narayana et al.

Oncotarget, 6(15), 12936-12954 (2015-05-24)

Helicobacter pylori infection is marked by a strong association with various gastric diseases, including gastritis, ulcers, and gastric cancer. Antibiotic treatment regimens have low success rates due to the rapid occurrence of resistant H. pylori strains, necessitating the development of

Metronidazole is still the drug of choice for treatment of anaerobic infections.

Sonja Löfmark et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 50 Suppl 1, S16-S23 (2010-01-14)

Metronidazole has been used for the treatment of infections for >45 years and is still successfully used for the treatment of trichomoniasis, amoebiasis, and giardiasis. Anaerobic bacterial infections caused by Bacteroides species, fusobacteria, and clostridia respond favorably to metronidazole therapy.

Treatment failure and recurrence of Clostridium difficile infection following treatment with vancomycin or metronidazole: a systematic review of the evidence.

Konstantinos Z Vardakas et al.

International journal of antimicrobial agents, 40(1), 1-8 (2012-03-09)

The objective of this review was to evaluate the frequency of treatment failure and recurrence of Clostridium difficile infection (CDI) following treatment with vancomycin or metronidazole in recently performed studies (last 10 years). Searches in PubMed and Scopus were performed

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Global Trade Item Number

SKU	GTIN
19-4497-2-25G-J	04061832685342