03-5330
γ-Butyrolactone
SAJ first grade, ≥99.5%
Synonym(s):
γ-Hydroxybutyric acid lactone, 4-Hydroxybutyric acid lactone, GBL
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About This Item
Empirical Formula (Hill Notation):
C4H6O2
CAS Number:
Molecular Weight:
86.09
PubChem Substance ID:
UNSPSC Code:
12352005
Beilstein/REAXYS Number:
105248
MDL number:
grade
SAJ first grade
vapor density
3 (vs air)
vapor pressure
1.5 mmHg ( 20 °C)
assay
≥99.5%
autoignition temp.
851 °F
expl. lim.
16 %
drug control
Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
availability
available only in Japan
refractive index
n20/D 1.436 (lit.)
bp
204-205 °C (lit.)
mp
−45 °C (lit.)
density
1.12 g/mL at 25 °C (lit.)
SMILES string
O=C1CCCO1
InChI
1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2
InChI key
YEJRWHAVMIAJKC-UHFFFAOYSA-N
Biochem/physiol Actions
Precursor of γ-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with γ-butyrolactone allows detection of autoreceptor-induced dopamine release.
Precursor of γ-hydroxybutyric acid (GHB); blocks dopamine release.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3
target_organs
Central nervous system
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
208.4 °F - closed cup
flash_point_c
98 °C - closed cup
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Monica Blichowski et al.
Epilepsia, 56(7), 1081-1087 (2015-06-03)
Infantile spasms (or IS) is a catastrophic childhood epilepsy that is particularly prevalent in children with Down syndrome. Previously, we have shown that the Ts65Dn (Ts) mouse model of Down syndrome is a useful substrate upon which to develop an
Jagan N Thupari et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(14), 9498-9502 (2002-06-13)
C75, a known inhibitor of fatty acid synthase is postulated to cause significant weight loss through decreased hypothalamic neuropeptide Y (NPY) production. Peripherally, C75, an alpha-methylene-gamma-butyrolactone, reduces adipose tissue and fatty liver, despite high levels of malonyl-CoA. To investigate this
Tezcan Guney et al.
Organic letters, 15(3), 613-615 (2013-01-18)
The total synthesis of paracaseolide A, a valuable cell-cycle progression inhibitor, was accomplished in 8 steps from known compounds, with 6.6% overall yield. The synthetic strategy creates strong potential for diversification.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 03-5330-5-500ML-J | 04061837739682 |