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MilliporeSigma

MAB3307

Sigma-Aldrich

Anti-MMP-1 Antibody, a.a. 332-350 hMMP1, clone 41-1E5

clone 41-1E5, Chemicon®, from mouse

Synonym(s):

Fibroblast Collagenase, Interstitial Collagenase

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

41-1E5, monoclonal

species reactivity

rabbit, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NM_002421.2

UniProt accession no.

P03956

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... MMP1(4312)

General description

52 kDa

Immunogen

Epitope: a.a. 332-350 hMMP1
Syntheic peptide aa332-350 of hMMP-1

Application

Anti-MMP-1 Antibody, a.a. 332-350 hMMP1, clone 41-1E5 detects level of MMP-1 & has been published & validated for use in ELISA, IH(P) & WB.
Immunoblotting:

Immunohistochemistry on PLP fixed, paraffin-embedded tissues 5-20μg/ml. PLP fixation required for best results. Antibody also reacts with frozen tissues. Reactivity on tradional formalin fixed tissue is poor. Microwave antigen retrieval is recommended

ElA

Biochem/physiol Actions

Specifically reacts with precursor and active forms of human MMP-1.

Physical form

Format: Purified
Liquid in 0.1 M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine Serum albumin.

Analysis Note

Control
Cervical carcinoma

SKBr-3 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-1122

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts.
Andreea M Bujor,Sashidar Nakerakanti,Erin Morris,Faye N Hant,Maria Trojanowska
Experimental Dermatology null
Immunohistochemical demonstration of collagenase and tissue inhibitor of metalloproteinases (TIMP) in synovial lining cells of rheumatoid synovium
Okada, Y. et al.
Virchows Archiv. B, Cell Pathology Including Molecular Pathology, 59, 305-312 (1990)
Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway.
Deroanne, CF; Hamelryckx, D; Ho, TT; Lambert, CA; Catroux, P; Lapiere, CM; Nusgens, BV
Journal of Cell Science null
A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 1 (interstitial collagenase) using monoclonal antibodies
Zhang, J. et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 219, 1-14 (1993)
Carine Strup-Perrot et al.
World journal of gastroenterology, 11(40), 6312-6321 (2006-01-19)
To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. Rats were exposed to a single 10-Gy dose of
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