AB5832
Anti-BACE Antibody
Chemicon®, from rabbit
Synonym(s):
ASP2, BACE1, Beta Secretase, beta-Site APP Cleaving Enzyme
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... BACE1(23621)
Immunogen
Synthetic peptide corresponding to amino acids 458 to 501 of human BACE (Vassar et al. 1999).
Application
Anti-BACE Antibody is an antibody against BACE for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blotting: 0.5-1.0 μg/mL on human brain tissue. The antibody recognizes a protein of molecular weight of 70 kDa in normal human brain lysate.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Reacts with human BACE by Western blot.
Physical form
Format: Purified
Purified immunoglobulin. Liquid. Buffer = PBS containing 0.02% sodium azide.
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 6 months.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Neuronal ?-amyloid generation is independent of lipid raft association of ?-secretase BACE1: analysis with a palmitoylation-deficient mutant.
Motoki, K; Kume, H; Oda, A; Tamaoka, A; Hosaka, A; Kametani, F; Araki, W
Brain and Behavior null
Naomi Mamada et al.
Molecular brain, 8(1), 73-73 (2015-11-11)
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is a membrane-bound aspartyl protease that initiates amyloid β-protein (Aβ) generation. Aberrant elevation of BACE1 levels in brains of Alzheimer's disease (AD) patients may involve Aβ. In the present study, we used
Daisuke Tanokashira et al.
eNeuro, 2(2) (2015-10-16)
The β-secretase called BACE1 is a membrane-associated protease that initiates the generation of amyloid β-protein (Aβ), a key event in Alzheimer's disease (AD). However, the mechanism of intraneuronal regulation of BACE1 is poorly understood. Here, we present evidence that low-density
R Yan et al.
Nature, 402(6761), 533-537 (1999-12-11)
Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP by unidentified proteases, referred to as beta- and gamma-secretases, generates the amyloid beta-peptide, the main component of the amyloid plaques found in
Expression of reticulon 3 in Alzheimer's disease brain.
H Kume,Y Konishi,K S Murayama,F Kametani,W Araki
Neuropathology and Applied Neurobiology null
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