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MilliporeSigma

C-046

Supelco

Cannabinol solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H26O2
CAS Number:
521-35-7
Molecular Weight:
310.43
EC Number:
200-659-6
MDL number:
MFCD00056774
UNSPSC Code:
41116107
PubChem Substance ID:
329774794
NACRES:
NA.24

Key Documents

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grade

certified reference material

Quality Level

300

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

cannabis testing
cannabis testing

format

single component solution

storage temp.

−20°C

SMILES string

CCCCCc1cc(O)c-2c(OC(C)(C)c3ccc(C)cc-23)c1

InChI

1S/C21H26O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9-13,22H,5-8H2,1-4H3

InChI key

VBGLYOIFKLUMQG-UHFFFAOYSA-N

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General description

The Certified Spiking Solution® is suitable for cannabinol testing by HPLC, GC/MS or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and Cannabis potency or impurity profiling testing applications.

Cannabinol is a phytocannabinoid that belongs to the class of C21 terpenophenolic compounds. Found in the cannabis plant it is a metabolite of Δ9-THC, the main psychoactive component of cannabis. Cannabinol is also the primary product of THC degradation from exposure to air and light.

Application

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Estimation of four cannabinoids from an oil matrix using reversed-phase high-performance liquid chromatography (RP-HPLC) combined with a diode array detector (DAD)
  • Simultaneous analysis of 11 cannabinoids in biomass and extracts of different cannabis varieties by an HPLC-UV method, following the International Conference on Harmonization (ICH) Tripartite Guideline for Validation of Analytical Procedures
  • Determination of eight cannabinoids in eight hemp samples and 12 forensic cannabis samples using reversed phase-high-pressure liquid chromatography (RP-HPLC) in combination with UV detector
  • Analysis of dried marijuana flowers to measure the amount of nine cannabinoids by high-performance liquid chromatography (HPLC) along with UV detection
  • Development and validation of an ultra high-performance liquid chromatographic (UHPLC) method coupled to photodiode array and mass spectrometry detectors to determine 11 cannabinoids in various Cannabis Sativa samples
  • Quantitative analysis of 17 cannabinoids in cannabis and hemp samples by LC-MS/MS following their liquid-solid extraction following AOAC and ASTM guidelines for cannabis and hemp matrices

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Raymond J M Niesink et al.
Addiction (Abingdon, England), 110(12), 1941-1950 (2015-08-04)
Between 2000 and 2005 the average percentage of Δ(9) -tetrahydrocannabinol (THC) in marijuana as sold in Dutch coffeeshops has increased substantially; the potency of domestic products (Nederwiet and Nederhasj) has particularly increased. In contrast with imported marijuana, Nederwiet hardly contained
F Van der Kooy et al.
Inhalation toxicology, 21(2), 87-90 (2008-10-16)
Medicinal cannabis has attracted a lot of attention in recent times. Various forms of administration are used, of which smoking is very common but the least desirable. Smoking cannabis generates a large amount of unwanted side products, of which carcinogenic
Penchal Reddy Nandaluru et al.
Organic letters, 14(1), 310-313 (2011-12-17)
A multicomponent domino reaction that affords 6H-dibenzo[b,d]pyran-6-ones is reported. The overall transformation consists of six reactions: Knoevenagel condensation, transesterification, enamine formation, an inverse electron demand Diels-Alder (IEDDA) reaction, 1,2-elimination, and transfer hydrogenation. Both the diene and dienophile for the key
Krishna Prasad Bastola et al.
Planta medica, 73(3), 273-275 (2007-03-14)
Cannabinoids, the main constituents of the cannabis plant, are being increasingly studied for their medicinal properties. Cannabinolic acid (CBNA; 1) was synthesized from tetrahydrocannabinolic acid (THCA; 2), a major constituent of the cannabis plant, by aromatization using selenium dioxide mixed
Dinesh Thapa et al.
European journal of pharmacology, 650(1), 64-71 (2010-10-19)
Both natural and synthetic cannabinoids have been shown to suppress the growth of tumor cells in culture and in animal models by affecting key signaling pathways including angiogenesis, a pivotal step in tumor growth, invasion, and metastasis. In our search
View All Related Papers

Articles

Optimización para el análisis de alto rendimiento de cannabinoides en diversas matrices utilizando la columna Ascentis® Express C18

Una completa secuencia de trabajo para la separación mediante HPLC de 17 cannabinoides en diferentes productos del cannabis utilizando la columna Ascentis® Express C18 en un tiempo de ejecución más corto con estabilidad de los tiempos de retención. Más información aquí.

Optimizing for High Throughput Analysis of Cannabinoids in a Variety of Matrices Using Ascentis® Express C18 Column

A complete workflow for the HPLC separation of 17 cannabinoids in different cannabis products using Ascentis® Express C18 Column in a shorter run time with retention time stability. Learn more here.

Cannabis Potency Testing: Method Dev. & Cost Considerations

Overview of gradient HPLC-based cannabinoid analysis optimized for key method parameters.

Cannabinoids Analysis Workflow with Chromolith® Column

HPLC-DAD workflow analyzes 14 cannabinoids in hemp extracts in 10 minutes using Chromolith columns for robust performance.

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Protocols

Analysis of 17 Cannabinoids in Hemp and Cannabis

HPLC separation of 17 important cannabinoids including CBD, delta 9 THC and THCA. Read the application note.

Analysis of Active Cannabis Compounds (Cannabinoids) in Edible Food Products: Gummy Bears and Brownies

Rapid potency testing of marijuana-infused edibles using LC/MS on a biphenyl stationary phase detected eleven cannabinoids.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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