764213
Biotin-PEG4-alkyne
for copper catalyzed click labeling
Synonym(s):
Polyethylene glycol, Acetylene-PEG4-biotin conjugate
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About This Item
Empirical Formula (Hill Notation):
C21H35N3O6S
CAS Number:
Molecular Weight:
457.58
MDL number:
UNSPSC Code:
12161502
PubChem Substance ID:
NACRES:
NA.22
Quality Level
assay
95%
form
solid
reaction suitability
reaction type: click chemistry
mp
55-64 °C
storage temp.
−20°C
SMILES string
O=C(NCCOCCOCCOCCOCC#C)CCCC[C@@H](SC1)[C@@]2([H])[C@]1([H])NC(N2)=O
InChI
1S/C21H35N3O6S/c1-2-8-27-10-12-29-14-15-30-13-11-28-9-7-22-19(25)6-4-3-5-18-20-17(16-31-18)23-21(26)24-20/h1,17-18,20H,3-16H2,(H,22,25)(H2,23,24,26)/t17-,18-,20-/m1/s1
InChI key
SKMJWNZZFUDLKQ-QWFCFKBJSA-N
Application
Biotinylation reagent for labeling azide containing molecules or biomolecules using copper-catalyzed 1,3 dipolar cycloaddition click chemistry. The alkyne group reacts with azides to form a stable triazole linkage, facilitating the introduction of biotin into your azide modified system of interest.
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)
Biotin-PEG4-alkyne may be used for the modification of 4-azidophenylalanine (AzPhe) silk fibroin via bioorthogonal azide–alkyne cycloaddition reaction for developing photopatternable protein material.
Other Notes
Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity
Fluorescent Heterotelechelic Single-Chain Polymer Nanoparticles: Synthesis, Spectroscopy, and Cellular Imaging
Arginine-Selective Chemical Labeling Approach for Identification and Enrichment of Reactive Arginine Residues in Proteins
Selective Imaging of Gram-Negative and Gram-Positive Microbiotas in the Mouse Gut
Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction
A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level
Fluorescent Heterotelechelic Single-Chain Polymer Nanoparticles: Synthesis, Spectroscopy, and Cellular Imaging
Arginine-Selective Chemical Labeling Approach for Identification and Enrichment of Reactive Arginine Residues in Proteins
Selective Imaging of Gram-Negative and Gram-Positive Microbiotas in the Mouse Gut
Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction
A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Anna Rutkowska et al.
ACS chemical biology, 11(9), 2541-2550 (2016-07-08)
Late stage failures of candidate drug molecules are frequently caused by off-target effects or inefficient target engagement in vivo. In order to address these fundamental challenges in drug discovery, we developed a modular probe strategy based on bioorthogonal chemistry that
Wei Wang et al.
Biochemistry, 56(30), 3889-3893 (2017-07-07)
The diverse gut microbial communities are crucial for host health. How the interactions between microbial communities and between host and microbes influence the host, however, is not well understood. To facilitate gut microbiota research, selective imaging of specific groups of
Bibudha Parasar et al.
ACS central science, 5(5), 867-873 (2019-05-30)
The metagenome of the gut microbiome encodes tremendous potential for biosynthesizing and transforming small-molecule metabolites through the activities of enzymes expressed by intestinal bacteria. Accordingly, elucidating this metabolic network is critical for understanding how the gut microbiota contributes to health
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 764213-10MG | 04061833230954 |
| 764213-5MG | 04061833230961 |