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394882

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

>97%

Synonym(s):

MTBSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)2C(CH3)3
CAS Number:
77377-52-7
Molecular Weight:
241.33
UNSPSC Code:
12352001
NACRES:
NA.22
PubChem Substance ID:
24864624
MDL number:
MFCD00009671
Beilstein/REAXYS Number:
3606546
Assay:
>97%
Form:
liquid
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Quality Level

200

grade

derivatization grade

assay

>97%

form

liquid

refractive index

n20/D 1.402 (lit.)

bp

172-175 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

functional group

amine, fluoro

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a highly reactive silylating reagent commonly used for silyation of carboxylic acids, alcohols, amines, and thiols. It is also used as a protection, deprotection reagent.

Application

N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) can be used:
  • As a derivatizing agent in the GC-MS analysis of hydroxylated fluorenes and in the GC analysis of amino acids.
  • As an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides.
  • To functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups.
MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization.

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pictograms

Flame
GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
1386289
1374742
1374743
1337050
03325JH

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Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Determination of β-blockers and β-agonists using gas chromatography and gas chromatography-mass spectrometry-a comparative study of the derivatization step
Caban M, et al.
Journal of Chromatography A, 1218(44), 8110-8122 (2011)
Silylation of multi-walled carbon nanotubes
Aizawa M, et al.
Chemical Physics Letters, 368(1-2), 121-124 (2003)
Tian-Xiang Wang et al.
Cell death & disease, 10(10), 755-755 (2019-10-09)
Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent lipid peroxidation and is implicated in several human pathologies, such as tissue ischemia, neurodegeneration, and cancer. Ferroptosis appears to be high cell-context dependent and the regulation of ferroptosis
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Global Trade Item Number

SKUGTIN
394882-10X1ML04061837790324
394882-100ML04061831982565
394882-25ML04061831982596
394882-5ML04061831982640