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218472

Sigma-Aldrich

Tetramethyl orthosilicate

98%

Synonym(s):

Tetramethoxysilane

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About This Item

Linear Formula:
Si(OCH3)4
CAS Number:
681-84-5
Molecular Weight:
152.22
Beilstein/REAXYS Number:
1699658
EC Number:
211-656-4
MDL number:
MFCD00008341
UNSPSC Code:
12352103
PubChem Substance ID:
24853068
NACRES:
NA.23

Key Documents

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vapor density

5.25 (vs air)

Quality Level

200

vapor pressure

13 hPa ( 20 °C)

assay

98%

form

liquid

refractive index

n20/D 1.368 (lit.)

bp

121-122 °C (lit.)

mp

−4 °C (lit.)

density

1.023 g/mL at 25 °C (lit.)

SMILES string

CO[Si](OC)(OC)OC

InChI

1S/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3

InChI key

LFQCEHFDDXELDD-UHFFFAOYSA-N

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General description

Tetramethyl orthosilicate (TMOS), also known as the methyl ester of orthosilicic acid, is a colorless liquid with low viscosity and is considered the most industrially significant among the tetraalkyl silicates. It is characterized by its excellent hydrolyzing and polymerizing properties, making it highly valuable in various chemical and material synthesis processes. It is insoluble in water.

Application

Tetramethyl orthosilicate is used as a silica source
  • In the synthesis of water-stable CsPbBr₃@SiO₂ perovskite nanocrystals, forming a protective siloxane network that enhances their stability for bioimaging applications
  • In the surface modification of magnetic nanoparticles to form a silica coating, enhancing their surface area and enabling efficient drug loading for targeted delivery applications.
  • To form a protective SiO₂ matrix around CsPbBr₃ quantum dots, enabling self-enhanced electrochemiluminescence for advanced optoelectronic applications
Used in the sol-gel synthesis of chromium-doped silicates and in the formation of hexagonal mesoporous silica layers.

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Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF9753
BCCB0710
BCBZ5464
BCBW8878
BCBW8877

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Yun Tian et al.
Electrophoresis, 29(4), 960-970 (2008-01-24)
A novel calix[4] open-chain crown ether (p-tert-butylcalix[4]arene-1,3-bis(allyloxyethy) ether)-modified, organic-inorganic hybrid silica-based monolithic column possessing vinyl ligands for CEC is described. The monolithic silica matrix containing a vinyl functionality was synthesized by in situ cocondensation of tetramethoxysilane (TMOS) and vinyltrimethoxysilane (VTMS)
Yonghao Xiu et al.
Journal of colloid and interface science, 326(2), 465-470 (2008-07-29)
A method for the preparation of inorganic superhydrophobic silica coatings using sol-gel processing with tetramethoxysilane and isobutyltrimethoxysilane as precursors is described. Incorporation of isobutyltrimethoxysilane into silica layers resulted in the existence of hydrophobic isobutyl surface groups, thereby generating surface hydrophobicity.
Josef Planeta et al.
Journal of chromatography. A, 1217(36), 5737-5740 (2010-08-03)
The temperature effects during the sol-gel process and ageing of the silica-based monolith on the structure and separation efficiency of the capillary columns (100microm i.d., 150mm) for HPLC separations were studied. The tested columns were synthesized from a mixture of
Yan Fang et al.
Journal of chromatography. A, 1217(41), 6405-6412 (2010-09-03)
A simple capillary flow porometer (CFP) was assembled for through-pore structure characterization of monolithic capillary liquid chromatography columns in their original chromatographic forms. Determination of differential pressures and flow rates through dry and wet short capillary segments provided necessary information
Shota Miyazaki et al.
Journal of chromatography. A, 1218(15), 1988-1994 (2010-12-24)
Chromatographic properties of a new type of monolithic silica rod columns were examined. Silica rod columns employed for the study were prepared from tetramethoxysilane, modified with octadecylsilyl moieties, and encased in a stainless-steel protective column with two polymer layers between
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