T7165
Tyrphostin 23
≥98%
Synonym(s):
(3,4-Dihydroxybenzylidene)malononitrile, RG-50810
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About This Item
Empirical Formula (Hill Notation):
C10H6N2O2
CAS Number:
Molecular Weight:
186.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
potency
35 μM IC50
solubility
DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1O)\C=C(\C#N)C#N
InChI
1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
InChI key
VTJXFTPMFYAJJU-UHFFFAOYSA-N
Gene Information
human ... CDK2(1017)
Application
Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Nathalie Leborgne-Castel et al.
Plant physiology, 146(3), 1255-1266 (2008-01-11)
The plant defense elicitor cryptogein triggers well-known biochemical events of early signal transduction at the plasma membrane of tobacco (Nicotiana tabacum) cells, but microscopic observations of cell responses related to these early events were lacking. We determined that internalization of
Sheung Kwan Lam et al.
The Plant journal : for cell and molecular biology, 60(5), 865-881 (2009-08-28)
Brefeldin A (BFA) is a useful tool for studying protein trafficking and identifying organelles in the plant secretory and endocytic pathways. At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome
Masaru Fujimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 6094-6099 (2010-03-17)
Endocytosis performs a wide range of functions in animals and plants. Clathrin-coated vesicle (CCV) formation is an initial step of endocytosis, and in animal cells is largely achieved by dynamins. However, little is known of its molecular mechanisms in plant
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T7165-5MG | 04061837372339 |
| T7165-25MG | 04061832452708 |