SAB4500888
Anti-FGFR3 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CD333, CD333 antigen, FGFR-3, Fibroblast growth factor receptor 3, JTK4
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
2
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 87 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FGFR3(2261)
General description
Anti-FGFR3 Antibody detects endogenous levels of total FGFR3 protein.
FGFR3 (fibroblast growth factor receptor 3) belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3.
Immunogen
The antiserum was produced against synthesized peptide derived from human FGFR3.
Immunogen Range: 131-180
Immunogen Range: 131-180
Application
Anti-FGFR3 antibody has been used in immunohistochemistry.
Biochem/physiol Actions
Germline mutations in FGFR3 (fibroblast growth factor receptor 3) results in autosomal dominant skeletal dysplasias like achondroplasia (ACH), thanatophoric dysplasia (TD) and hypochrondroplasia (HCH). The gene also controls cellular activity.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma
Sibley K, et al.
Oncogene, 20, 686-691 (2001)
Masanobu Kawai et al.
The Journal of biological chemistry, 288(4), 2414-2427 (2012-12-14)
Fibroblast growth factor-23 (FGF23) is well established to play crucial roles in the regulation of phosphate homeostasis. X-linked hypophosphatemic rickets (XLH) is characterized by impaired mineralization and growth retardation associated with elevated circulating FGF23 levels. Administration of phosphate and calcitriol
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4500888-100UG | 04061837744280 |