S1688
SR 57227A
solid
Synonym(s):
4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H14ClN3 · HCl
CAS Number:
Molecular Weight:
248.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
solubility
H2O: soluble 9 mg/mL
SMILES string
Cl.NC1CCN(CC1)c2cccc(Cl)n2
InChI
1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
InChI key
FUMINTAAUJUVMP-UHFFFAOYSA-N
Gene Information
human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
Application
SR 57227A may be used in 5-HT3-mediated cell signaling studies.
Biochem/physiol Actions
Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Taha Gholipour et al.
Seizure, 19(1), 17-22 (2009-11-28)
There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the
Qiao Jun Zhang et al.
Brain research, 1384, 69-79 (2011-02-05)
In the present study, effect of SR 57227A, a selective 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist, on the firing activity of pyramidal neurons in the medial prefrontal cortex (mPFC) was studied in normal rats and rats with 6-hydroxydopamine lesions of the substantia
M Poncelet et al.
Journal of neural transmission. General section, 102(2), 83-90 (1995-01-01)
We have investigated the effect of SR 57227A, a selective 5-HT3 receptor agonist which crosses the blood brain barrier, on three rodent models in which antidepressants are active. In the forced swimming test, SR 57227A dose-dependently reduced the duration of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S1688-5MG | 04061832093383 |