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P9159

Piperidine-4-sulfonic acid

Name: Piperidine-4-sulfonic acid
Brand: SIGMA

Synonym(s):

P4S

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About This Item

Empirical Formula (Hill Notation):

C₅H₁₁NO₃S

CAS Number:

72450-62-5

Molecular Weight:

165.21

NACRES:

NA.77

PubChem Substance ID:

24278165

UNSPSC Code:

12352106

MDL number:

MFCD00055097

Form:

powder

Quality level:

200

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Properties

form

powder

Quality Level

200

SMILES string

OS(=O)(=O)C1CCNCC1

InChI

1S/C5H11NO3S/c7-10(8,9)5-1-3-6-4-2-5/h5-6H,1-4H2,(H,7,8,9)

InChI key

UGBJGGRINDTHIH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

Biochem/physiol Actions

GABA_A receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

Propofol increases agonist efficacy at the GABA(A) receptor.

S M O'Shea et al.

Brain research, 852(2), 344-348 (2000-03-11)

Using the whole-cell patch-clamp technique, we have determined that propofol, but not midazolam, increases the efficacy of piperidine-4-sulphonic acid (P4S), a partial agonist at alpha1beta1gamma2s, GABA(A) receptors expressed in HEK 293 cells. These findings are consistent with the idea that

Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.

Norbert Topf et al.

Anesthesiology, 98(2), 306-311 (2003-01-29)

Volatile anesthetics prolong inhibitory postsynaptic potentials in central neurons an allosteric action on the gamma-aminobutyric acid type A (GABA(A)) receptor, an effect that may underlie the hypnotic actions of these agents. Inhaled anesthetics such as isoflurane act to enhance responses

Identifying agonistic and antagonistic mechanisms operative at the GABA receptor.

E Galvez-Ruano et al.

Journal of neuroscience research, 42(5), 666-673 (1995-12-01)

Based on our molecular modeling investigations of the glycinergic receptor, we expanded our studies to similarly investigate the GABAergic receptor. New data suggest there may exist a slightly different agonistic mechanism for the molecules described herein as compared to glycine.

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Global Trade Item Number

SKU	GTIN
P9159-250MG	04061832083704
P9159-25MG	04061832083711