N1019
(−)-Nicotine hemisulfate salt
≥95% (TLC), ~35 % (w/v) in H2O (based on free base)
Synonym(s):
(−)-1-Methyl-2-(3-pyridyl)pyrrolidine
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About This Item
Linear Formula:
(C10H14N2)2 · H2SO4
CAS Number:
Molecular Weight:
422.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
MDL number:
Quality Level
assay
≥95% (TLC)
form
liquid
concentration
~35 % (w/v) in H2O (based on free base)
color
dark brown
SMILES string
OS(O)(=O)=O.CN1CCC[C@H]1c2cccnc2.CN3CCC[C@H]3c4cccnc4
InChI
1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;(H2,1,2,3,4)/t2*10-;/m00./s1
InChI key
IECQULMJVNSKDB-RCWTXCDDSA-N
Gene Information
human ... CHRNA4(1137), CHRNB2(1141)
General description
Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.
Application
(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.
Biochem/physiol Actions
Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
Analysis Note
Mixture of nicotine base and nicotine sulfate.
Disclaimer
Shelf-life of the solution as supplied is at least six years when stored at room temperature.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
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Behavioural evidence for self-medication in bumblebees
Baracchi D, et al.
F1000Research, 4(1) (2015)
Nicotine increases size and severity of experimental choroidal neovascularization
Suner IJ, et al.
Investigative Ophthalmology & Visual Science, 45(1), 311-317 (2004)
Caiqi Zhao et al.
Cell discovery, 3, 17009-17009 (2017-05-23)
Vagal circuits-α7 nAChR (α7 nicotinic acetylcholine receptor, coded by
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N1019-25ML | 04061834093206 |
| N1019-100ML | 04061838173386 |