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H9377

Hypoxanthine

Name: Hypoxanthine
Brand: SIGMA

≥99.0%, synthetic (organic), powder

Synonym(s):

6-Hydroxypurine

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About This Item

Empirical Formula (Hill Notation):

C₅H₄N₄O

CAS Number:

68-94-0

Molecular Weight:

136.11

NACRES:

NA.51

PubChem Substance ID:

24895850

UNSPSC Code:

41106305

EC Number:

200-697-3

MDL number:

MFCD00005725

Beilstein/REAXYS Number:

5811

Assay:

≥99.0%

Biological source:

synthetic (organic)

Form:

powder

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Properties

Product Name

Hypoxanthine, ≥99.0%

biological source

synthetic (organic)

Quality Level

300

assay

≥99.0%

form

powder

SMILES string

O=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChI key

FDGQSTZJBFJUBT-UHFFFAOYSA-N

Description

Application

Hypoxanthine has been used:

to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia
as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells)
as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-violet (HPLC-UV) for the estimation of post-mortem interval

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Biochem/physiol Actions

Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position. It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

HPLC Analysis of Xanthines on Purospher® STAR RP-18 endcapped

Separation of Hypoxanthine, ≥99.0%; Xanthine, ≥99%; 7-Methylxanthine, ≥98.0% (HPLC); 3-Methylxanthine; 1-Methylxanthine, ≥97.0% (HPLC); Theobromine, ≥98.0%; 1,7-Dimethylxanthine, ~98%, solid; Theophylline, anhydrous, ≥99%, powder; Specimen capsules, microporous, average pore diameter 120 μm

Uric Acid in Cell Culture

Uric acid is not a direct additive to any of the classical cell culture media. However, it is present in animal sera. Consequently, uric acid is typically present in complete serum-supplemented classical cell culture systems.

Uric Acid in Cell Culture

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

Different processed milk with residual xanthine oxidase activity and risk of increasing serum uric acid level

Sha W, et al.

Food Bioscience (2021)

Influence of the nature of death in biochemical analysis of the vitreous humour for the estimation of post-mortem interval

Perez-Martinez C, et al.

Australian journal of public health (2020)

In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling.

John V W Becker et al.

Malaria journal, 10, 295-295 (2011-10-12)

Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial agents from South African medicinal plants. One of

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Global Trade Item Number

SKU	GTIN
H9377-1G	04061835557219
H9377-100G	04061835545711
H9377-25G	04061835516100
H9377-5G	04061835545728