G002
Isoguvacine hydrochloride
solid
Synonym(s):
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C6H9NO2 · HCl
CAS Number:
Molecular Weight:
163.60
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
solubility
H2O: soluble (refrigerate if not used immediately.), methanol: slightly soluble, neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)
SMILES string
Cl[H].OC(=O)C1=CCNCC1
InChI
1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
InChI key
SUWREQRNTXCCBL-UHFFFAOYSA-N
Gene Information
Application
Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABAA) receptor agonist:
- to study its effects on neuronal activity in rats
- to study its antiallodynic effect in rats
- to study its effects on baroreflex gains in rats
Biochem/physiol Actions
Isoguvacine is a strong γ-aminobutyric acid A (GABAA) receptor agonist.
Features and Benefits
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Articles
DISCOVER Bioactive Small Molecules for Neuroscience
Roman Tyzio et al.
Epilepsia, 48 Suppl 5, 96-105 (2007-10-04)
The timing of the developmental switch in the GABA(A) mediated responses from excitatory to inhibitory was studied in Wistar rat CA3 hippocampal pyramidal cells using gramicidin perforated patch-clamp and extracellular recordings. Gramicidin perforated patch recordings revealed a gradual developmental shift
Ke-Zhong Shen et al.
The Journal of physiology, 573(Pt 3), 697-709 (2006-04-15)
The subthalamic nucleus (STN) plays an important role in movement control by exerting its excitatory influence on the substantia nigra pars reticulata (SNR), a major output structure of the basal ganglia. Moreover, excessive burst firing of SNR neurons seen in
Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds.
P Krogsgaard-Larsen et al.
Journal of neurochemistry, 30(6), 1377-1382 (1978-06-01)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G002-100MG | 04061832090887 |
| G002-25MG | 04061833623169 |