E1279
Enoximone
solid
Synonym(s):
1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one
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About This Item
Empirical Formula (Hill Notation):
C12H12N2O2S
CAS Number:
Molecular Weight:
248.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
light yellow
solubility
DMSO: soluble 28 mg/mL
SMILES string
CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2
InChI
1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)
InChI key
ZJKNESGOIKRXQY-UHFFFAOYSA-N
Gene Information
human ... PDE3A(5139), PDE3B(5140)
Biochem/physiol Actions
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE.
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Related Content
S Schauvliege et al.
Equine veterinary journal, 41(8), 778-785 (2010-01-26)
No studies have been reported on the effects of enoximone in anaesthetised colic horses. To examine whether enoximone improves cardiovascular function and reduces dobutamine requirement in anaesthetised colic horses. Forty-eight mature colic horses were enrolled in this prospective, randomised clinical
H J Gilfrich et al.
Zeitschrift fur Kardiologie, 80 Suppl 4, 93-97 (1991-01-01)
Enoximone, a new phosphodiesterase-inhibitor with positive inotropic and vasodilating activities is available for intravenous use in patients with severe heart failure. A review of the current knowledge regarding the adverse effects of this substance reveals that they are characterized by
B Hausen et al.
European heart journal, 13(5), 679-686 (1992-05-01)
Inotropic support is often required for post-operative management of patients following mitral valve operation. The use of positive inotropes is limited by tolerance development and increase in myocardial oxygen demand. We have compared i.v. enoximone (E) (group E, n =
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E1279-10MG | 04061833629697 |
| E1279-50MG | 04061833629703 |