Key Documents

View All Documentation

D0633

7-(2,3-Dihydroxypropyl)theophylline

Name: 7-(2,3-Dihydroxypropyl)theophylline
Brand: SIGMA

PDE inhibitor, powder

Synonym(s):

7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, Diprophylline, Dyphylline

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₄O₄

CAS Number:

479-18-5

Molecular Weight:

254.24

NACRES:

NA.77

PubChem Substance ID:

24893280

UNSPSC Code:

41106305

EC Number:

207-526-1

MDL number:

MFCD00005759

Beilstein/REAXYS Number:

284563

Form:

powder

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

7-(2,3-Dihydroxypropyl)theophylline,

form

powder

mp

161-162 °C (lit.)

SMILES string

CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O

InChI

1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

InChI key

KSCFJBIXMNOVSH-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Description

Biochem/physiol Actions

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Modeling drug release from PVAc/PVP matrix tablets.

F Siepmann et al.

Journal of controlled release : official journal of the Controlled Release Society, 141(2), 216-222 (2009-09-10)

Kollidon SR-based matrix tablets containing various amounts of diprophylline were prepared and thoroughly characterized in vitro. This includes drug release measurements in 0.1M HCl and phosphate buffer pH 7.4, monitoring of changes in the tablet's height and diameter, morphology as

Drug release from extruded solid lipid matrices: theoretical predictions and independent experiments.

Sinan Güres et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(1), 122-129 (2011-10-20)

The aim of this study was to use a mechanistically realistic mathematical model based on Fick's second law to quantitatively predict the release profiles from solid lipid extrudates consisting of a ternary matrix. Diprophylline was studied as a freely water-soluble

Simultaneous determination of theophylline and dyphylline by micellar electrokinetic chromatography and application in drug formulations.

Wei-Shan Huang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 795(2), 329-335 (2003-10-03)

A simple micellar electrokinetic chromatography is described for well resolution of theophylline, dyphylline and caffeine. The separation was performed at 25 degrees C using a background electrolyte consisting of 10mM borate buffer at pH 9 and 40 mM sodium dodecyl

View All Related Papers

Global Trade Item Number

SKU	GTIN
D0633-500G	04061832897783
D0633-1KG	04061826744314