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C1254

Sodium cholate hydrate

Name: Sodium cholate hydrate
Brand: SIGMA

from bovine and/or ovine bile, ≥99%

Synonym(s):

3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₉NaO₅ · xH₂O

CAS Number:

206986-87-0

Molecular Weight:

430.55 (anhydrous basis)

UNSPSC Code:

12161900

NACRES:

NA.25

PubChem Substance ID:

24892390

EC Number:

206-643-5

Beilstein/REAXYS Number:

3582354

MDL number:

MFCD00150749

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Properties

biological source

bovine and/or ovine bile

Quality Level

200

description

anionic

assay

≥99%

form

powder

mol wt

micellar avg mol wt 900-1300

aggregation number

2-3

technique(s)

DNA purification: suitable, RNA purification: suitable, western blot: suitable

CMC

9-15 mM (20-25°C)

solubility

water: 100 mg/mL, clear, colorless to light yellow

HLB

SMILES string

O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C

InChI

1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1

InChI key

MUVVIYFKOVLQHL-RCVKHMDESA-M

Description

General description

Sodium cholate hydrate, a non-denaturing anionic detergent, plays a crucial role in biochemical research, particularly in protein solubilization and membrane permeabilization, making it essential for protein extraction and purification, especially when dealing with membrane proteins and protein complexes. Derived from cholic acid, a prevalent human bile acid, sodium cholate hydrate′s water solubility and its applications extend to investigating the effects of various substances on cell cultures, making it a versatile tool in laboratory research.

Application

Sodium cholate hydrate has been used in a study to assess the effect of phospholipid formulation and surfactants on the dermal delivery of hydrophilic drugs from elastic liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.

Biochem/physiol Actions

Bile Salt

Features and Benefits

Suitable for Western blotting
Suitable for DNA and RNA purification
High purity product for research applications

Other Notes

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hcodes

H412

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Probiotics and Human Health

Today, diverse studies report the benefits of probiotics, such as inhibitory effects on pathogens, aid in the management or prevention of chronic intestinal inflammatory diseases or atopic syndromes, and support to the immune system. Potential beneficial applications abound, researchers continue to evaluate the effictiveness and clarify the mechanisms of action of probiotics.

Probiotics and Human Health

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants.

Kevin B Ita et al.

The Journal of pharmacy and pharmacology, 59(9), 1215-1222 (2007-09-22)

The effect of phospholipid formulation and choice of surfactant on skin permeation of selected hydrophilic drugs from elastic liposomes across human epidermal membrane has been studied. Sodium cholate and various concentrations of phosphatidylcholine were used for the preparation of liposomes

Transfersomes for transdermal drug delivery

Benson, H.

Expert Opinion on Drug Delivery, 3, 727-727 (2005)

Controllable synthesis of water-soluble gold nanoparticles and their applications in electrocatalysis and surface-enhanced Raman scattering.

Yan Qiao et al.

Langmuir : the ACS journal of surfaces and colloids, 27(17), 11090-11097 (2011-07-19)

We report a facile method to synthesize water-soluble gold nanoparticles (AuNPs) using a biosurfactant sodium cholate as reducing reagents and protective groups in aqueous solution at ambient temperature. The diameters (13-70 nm) of uniform AuNPs can be readily adjusted by

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Global Trade Item Number

SKU	GTIN
C1254-5KG	04061833467237
C1254-500G	04061833467220
C1254-100G	04061835543151
C1254-1KG	04061833467206
C1254-25G	04061833467213