B3306
Bisindolylmaleimide IV
≥98% (TLC), solid
Synonym(s):
Ro 31-6233
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About This Item
Empirical Formula (Hill Notation):
C20H13N3O2
CAS Number:
Molecular Weight:
327.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
solid
color
dark red
solubility
DMSO: soluble, methanol: soluble
storage temp.
−20°C
SMILES string
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45
InChI
1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChI key
DQYBRTASHMYDJG-UHFFFAOYSA-N
Gene Information
human ... CDK2(1017), EGFR(1956)
rat ... Prkca(24680)
Biochem/physiol Actions
Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI. BIMs act as an inhibitor of protein kinase C (PKC). They are derived from staurosporine. BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| B3306-1MG | 04061833427651 |
| B3306-5MG | 04061833427668 |