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271012

N,N-Dimethylacetamide

Name: <I>N,N</I>-Dimethylacetamide
Brand: SIAL

anhydrous, 99.8%

Synonym(s):

DMAc

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About This Item

Linear Formula:

CH₃CON(CH₃)₂

CAS Number:

127-19-5

Molecular Weight:

87.12

UNSPSC Code:

12352111

NACRES:

NA.21

PubChem Substance ID:

57648218

EC Number:

204-826-4

Beilstein/REAXYS Number:

1737614

MDL number:

MFCD00008686

Assay:

99.8%

Grade:

anhydrous

Bp:

164.5-166 °C (lit.)

Vapor pressure:

2 mmHg ( 25 °C), 4 mmHg ( 38 °C)

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Properties

grade

anhydrous

Quality Level

300

vapor density

3 (vs air)

vapor pressure

2 mmHg ( 25 °C), 4 mmHg ( 38 °C)

assay

99.8%

form

liquid

autoignition temp.

914 °F

expl. lim.

1.8 %, 100 °F, 11.5 %, 160 °F

impurities

<0.005% water

evapn. residue

<0.001%

refractive index

n20/D 1.437 (lit.)

pH

4 (20 °C, 200 g/L)

bp

164.5-166 °C (lit.)

mp

−20 °C (lit.)

density

0.937 g/mL at 25 °C (lit.)

SMILES string

CN(C)C(C)=O

InChI

1S/C4H9NO/c1-4(6)5(2)3/h1-3H3

InChI key

FXHOOIRPVKKKFG-UHFFFAOYSA-N

Description

Application

N,N-Dimethylacetamide may be used as a solvent in the following processes:

Palladium (II) acetate-butyldi-1-adamantylphosphine catalyzed arylation of 2-isobutylthiazole with chlorobenzene to form 5-phenyl-2-isobutylthiazole.
Synthesis of β-, γ-, and δ-metallo ester intermediates that can react with acid chlorides to form γ-, δ-, and ε-keto esters.
Synthesis of (R)-(-)-methyl 1,1′-binaphthyl-2,2′-diylphosphate that can be used as a precursor for preparing (R)-(+)-1,1′-binaphthalene-2,2′-diol.

Packaging

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Other Notes

The article number 271012-4X2L will be discontinued. Please order the single bottle 271012-2L which is physically identical with the same exact specifications.

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H312 + H332,H319,H360D

pcodes

P202 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

147.2 °F - closed cup

flash_point_c

64 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Articles

Scale-Up Guide: Buchwald-Hartwig Amination Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form. Once activated by base under the reaction conditions they become sensitive to air. To best enable scale-up success, the use of standard Schlenk technique is recommended.

Scale-Up Guide: Buchwald-Hartwig Amination

Preformed catalysts in the kit are stable but become air-sensitive when activated; Schlenk technique aids scale-up.