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W421501

Tyramine

Name: Tyramine
Brand: ALDRICH

98%, FG

Synonym(s):

2-(4-Hydroxyphenyl)ethylamine, 4-(2-Aminoethyl)phenol, 4-Hydroxyphenethylamine

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About This Item

Linear Formula:

HOC₆H₄CH₂CH₂NH₂

CAS Number:

51-67-2

Molecular Weight:

137.18

Flavis number:

11.007

PubChem Substance ID:

329830683

UNSPSC Code:

12164502

FEMA Number:

4215

NACRES:

NA.21

EC Number:

200-115-8

MDL number:

MFCD00008193

Beilstein/REAXYS Number:

1099914

Organoleptic:

meaty; phenolic

Grade:

Biological source:

synthetic

Food allergen:

no known allergens

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Properties

biological source

synthetic

Quality Level

300, 400

grade

reg. compliance

EU Regulation 1334/2008 & 872/2012, FDA 21 CFR 110

assay

98%

bp

175-181 °C/8 mmHg (lit.)

mp

160-162 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

meaty; phenolic

SMILES string

NCCc1ccc(O)cc1

InChI

1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2

InChI key

DZGWFCGJZKJUFP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Can enter catecholaminergic terminals and be released as a false transmitter.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

21496DJ

02124AE

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Neurovascular dissociation with paradoxical forearm vasodilation during systemic tyramine administration.

Giris Jacob et al.

Circulation, 107(19), 2475-2479 (2003-04-23)

Despite the widespread use of tyramine as a pharmacological tool to assess the effects of norepinephrine release from sympathetic nerve terminals, its vascular effects are not adequately characterized. In particular, previous results indicate that intravenous tyramine produces little if any

Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice.

Tony Huynh et al.

The Journal of pathology, 231(2), 223-235 (2013-06-25)

The over-expression of NF-κB signalling in both muscle and immune cells contribute to the pathology in dystrophic muscle. The anti-inflammatory properties of glucocorticoids, mediated predominantly through monomeric glucocorticoid receptor inhibition of transcription factors such as NF-κB (transrepression), are postulated to

Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study.

Stephan A Chalon et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 28(9), 1685-1693 (2003-06-05)

Evidence suggests that compounds that increase the synaptic availability of more than one neurotransmitter have greater efficacy in the treatment of depression than single-acting drugs. Preclinical studies indicate that duloxetine acts to inhibit serotonin (5-HT) and norepinephrine (NE) transporters. The

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Global Trade Item Number

SKU	GTIN
T62804-5G	04061837365584
T62804-100G	04061838357083
T62804-25G	04061837364730
W421501-100G	04061834406631
W421501-25G	04061835567584
W421501-SAMPLE	04061834357148