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SRP0349

Flt3 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Synonym(s):

CD135, FLK2, STK1, fms-related tyrosine kinase 3

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About This Item

CAS Number:
1688608-05-0
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
aqueous solution
Assay:
≥80% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
54.2 kDa
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biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

54.2 kDa

packaging

pkg of 10 μg

technique(s)

activity assay: suitable, inhibition assay: suitable

NCBI accession no.

NM_004119

UniProt accession no.

P36888

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FLT3(2322)

General description

Human Flt3 (GenBank Accession No. NM_004119), amino acids 564-end with N-terminal His-tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Connor P Hall et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(3), 621-632 (2015-06-18)
The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in acute lymphoblastic leukemia (ALL). The cytotoxic effects of BEZ235 and dexamethasone as single
Mark Levis et al.
Blood, 106(2), 673-680 (2005-03-31)
Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a poor overall survival. While the normal FLT3 receptor is expressed in early hematopoietic progenitor
Shinichiro Takahashi et al.
Leukemia research, 29(8), 893-899 (2005-06-28)
Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B
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Global Trade Item Number

SKUGTIN
SRP0349-10UG04061837195907