SML4250
t-TUCB
≥97% (HPLC)
Synonym(s):
4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid, trans-4-[4-[3-(4-Trifluoromethoxyphenyl)ureido]cyclohexyloxy]benzoic acid, EC 1728, EC-1728, EC1728, UC 1728, UC-1728, UC1728
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About This Item
Empirical Formula (Hill Notation):
C21H21F3N2O5
CAS Number:
Molecular Weight:
438.40
MDL number:
Quality Level
Assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Orally active and potent soluble epoxide hydrolase (sEH) inhibitor that modulates inflammation and autophagy in obese fat-1 mice.
t-TUCB is an orally active and potent soluble epoxide hydrolase (sEH) inhibitor (h/m/r IC50 = 0.9/1.3/16 nM). t-TUCB modulates inflammation and autophagy in adipose tissue and liver in obese fat-1 mice (10 μg/mL in drinking water, ∼1.67 mg/kg/d). When administered at 10 mg/kg via s.c. t-TUCB is substantially more effective than t-AUCB and APAU in a diabetic neuropathy model in rats.
t-TUCB is an orally active and potent soluble epoxide hydrolase (sEH) inhibitor (h/m/r IC50 = 0.9/1.3/16 nM). t-TUCB modulates inflammation and autophagy in adipose tissue and liver in obese fat-1 mice (10 μg/mL in drinking water, ∼1.67 mg/kg/d). When administered at 10 mg/kg via s.c. t-TUCB is substantially more effective than t-AUCB and APAU in a diabetic neuropathy model in rats.
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