RAB0750
Human PLAUR / Urokinase Plasminogen Activator Surface Receptor ELISA Kit
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 15 pg/mL
standard curve range: 16.38-4000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PLAUR(5329)
General description
The antibody pair provided in this kit recognizes human Urokinase Plasminogen Activator Surface Receptor.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Plasminogen activator, urokinase receptor (PLAUR) is implicated in tumor invasion, angiogenesis and metastasis. It acts as a key regulator of cell-surface plasminogen activator. It is involved in various normal and pathological processes. Overexpression of the gene has been observed in various types of cancers, including head and neck squamous cell carcinoma (HNSCC). Thus, it is considered as an potent biomarker for targeted imaging or therapy. Elevated expression of PLAUR leads to the progression of kidney disease in children.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Fei Huang et al.
Mediators of inflammation, 2020, 7850179-7850179 (2020-04-24)
The soluble urokinase plasminogen activator receptor (suPAR) is associated with kidney diseases and is used as a prognostic factor of renal function progression. The aim of this study was to explore whether circulating suPAR was associated with antineutrophil cytoplasmic autoantibody-
Ümmügülsüm Can et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 62(7), 938-943 (2014-08-16)
Chronic obstructive pulmonary disease (COPD) results from an abnormal inflammatory response of the lungs to noxious particles or gases. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is a glycoprotein secreted during infections and inflammation. The main goal of this study
Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children.
Schaefer F, et al.
JAMA Pediatrics, 171(11), e172914-e172914 (2017)
Sven Wach et al.
Molecular therapy. Nucleic acids, 16, 272-283 (2019-04-02)
MIR143 is pathologically downregulated and may function as a tumor suppressor in prostate cancer. Likewise, the urokinase plasminogen activator receptor (UPAR) is overexpressed in prostate carcinoma, representing a negative prognostic marker and putative therapeutic target gene. In this paper, we
uPAR-targeted optical near-infrared (NIR) fluorescence imaging and PET for image-guided surgery in head and neck cancer: proof-of-concept in orthotopic xenograft model
Christensen A, et al.
Oncotarget, 8(9), 15407-15407 (2017)
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