P5372
Anti-Potassium Channel Kv7.1 (KCNQ1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-KVLQT1, Anti-Voltage-gated potassium channel QKT subfamily member 1
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat, human
technique(s)
western blot: 1:200 using rat heart membranes
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KCNQ1(3784)
mouse ... Kcnq1(16535)
rat ... Kcnq1(84020)
General description
Potassium Channel Kv7.1 (KCNQ1) encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins,
Immunogen
synthetic peptide corresponding to amino acid residues 661-676 of human KCNQ1. This sequence has 14/16 residues identical in rat and mouse.
Biochem/physiol Actions
Does not cross react with other QKT proteins.
Physical form
Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
13 - Non Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
Christian A Hübner et al.
Human molecular genetics, 11(20), 2435-2445 (2002-09-28)
Ion channels serve many functions apart from electrical signal transduction: chemical signalling (Ca(2+) as a second messenger), transepithelial transport, regulation of cytoplasmic or vesicular ion concentration and pH, and regulation of cell volume. Therefore, ion channel dysfunction can cause diseases
Kazuya Yamagata et al.
Biochemical and biophysical research communications, 407(3), 620-625 (2011-03-24)
KCNQ1, located on 11p15.5, encodes a voltage-gated K(+) channel with six transmembrane regions, and loss-of-function mutations in the KCNQ1 gene cause hereditary long QT syndrome. Recent genetic studies have identified that single nucleotide polymorphisms located in intron 15 of the
J Robbins
Pharmacology & therapeutics, 90(1), 1-19 (2001-07-13)
KCNQ genes encode a growing family of six transmembrane domains, single pore-loop, K(+) channel alpha-subunits that have a wide range of physiological correlates. KCNQ1 (KvLTQ1) is co-assembled with the product of the KCNE1 (minimal K(+)-channel protein) gene in the heart
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P5372-200UL | 04061837813658 |