I1637
Ipratropium bromide monohydrate
≥98% (TLC), powder
Synonym(s):
Atropine isopropyl bromide
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About This Item
Empirical Formula (Hill Notation):
C20H30BrNO3 · H2O
CAS Number:
Molecular Weight:
430.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-873-8
MDL number:
Quality Level
assay
≥98% (TLC)
form
powder
color
white
solubility
H2O: 10 mg/mL
originator
Boehringer Ingelheim
SMILES string
O.[Br-].CC(C)[N@+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
InChI
1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19?,21?;;
InChI key
KEWHKYJURDBRMN-XSAPEOHZSA-M
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
Application
Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats.
Biochem/physiol Actions
Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β2 adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.
Features and Benefits
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
N-isopropyl quaternary salt of atropine.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
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P J Barnes
Chest, 117(2 Suppl), 63S-66S (2000-02-16)
Tiotropium is a long-acting anticholinergic drug. Studies with cloned human muscarinic receptors show that tiotropium binds equally well to M(1), M(2), and M(3) receptors. However, it dissociates very slowly from M(1) and M(3) receptors compared with ipratropium, and more rapidly
H Groeben et al.
Anesthesiology, 85(4), 867-873 (1996-10-01)
Two major groups of drugs are available to prevent bronchoconstriction: beta-agonists and muscarinic blocking agents. Ipratropium is the most commonly used anticholinergic agent to treat chronic obstructive pulmonary disease. The authors studied anti-muscarinic agents to determine if they are as
Bilateral acute angle closure developing due to use of ipratropium bromide and salbutamol.
Kola M, et al.
International Ophthalmology, 38(1), 385-388 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I1637-1G | 04061833847893 |
| I1637-250MG | 04061833847909 |