1.06018
Methanol
≥99.8% (GC), HPLC grade, suitable for HPLC, LiChrosolv®
Synonym(s):
MeOH, Hydroxymethane, Carbinol, Methyl alcohol
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About This Item
Product Name
Methanol, for liquid chromatography LiChrosolv®
grade
HPLC grade
Quality Level
vapor density
1.11 (vs air)
vapor pressure
128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)
description
isocratic
product line
LiChrosolv®
assay
≥99.8% (GC)
form
liquid
autoignition temp.
725 °F
potency
5628 mg/kg LD50, oral (Rat), 17100 mg/kg LD50, skin (Rabbit)
technique(s)
HPLC: suitable
impurities
≤0.0002 meq/g Acidity, ≤0.0002 meq/g Alkalinity, ≤0.03% Water
evapn. residue
≤3.0 mg/L
color
APHA: ≤10
transmittance
225 nm, ≥50%, 240 nm, ≥80%, 265 nm, ≥98%
kinematic viscosity
0.54-0.59 cSt(20 °C)
mp
−98 °C (lit.)
transition temp
flash point 9.7 °C
format
neat
storage temp.
2-30°C
General description
Application
Featured in method development of:
- Benazepril - USP Method Benazepril RS
- Betamethasone - USP Method Betamethasone Valerate Assay
- Irbesartan - USP Method Irbesartan Assay
- Lamivudine - USP Method Lamivudine RS
- Lansoprazole - USP Method Lansoprazole RS
- Levofloxacin - USP Method Levofloxacin RS - USP Method Levofloxacin Assay
- Nifedipine - USP Method Nifedipine RS - USP Method Nifedipine Assay
- Pharmacopoeia Monograph Methods - HPLC and UHPLC methods for Regulated Drug Analysis
- Pioglitazone - USP Method Pioglitazone HCl RS - USP Method Pioglitazone HCl Assay
Features and Benefits
- suitability tested and specified for UHPLC-MS and UHPLC-UV: for analytical flexibility
- specified quality in positive and negative in positive and negative electrospray ionization (ESI) and atmospheric-pressure chemical ionization-mass spectrometry (APCI-MS) for lowest detection limits and confidence in analyses for all important MS modes (test 1)
—ESI/APCI (+) < 2 ppb
—ESI/APCI (-) < 10 ppb - lowest impurity profile: for interference-free baselines (test 2)
- microfiltered through 0.2 μm filter (test 3) to provide:
—A long lifespan to filters and mechanical parts of HPLC systems
––reduced risk of column clogging - packaged in borosilicate glass bottles for minimized metal ion contaminations
- lowest levels of trace metal impurities for a minimum metal ion adduct formation
—<5 ppb - lowest level of polyethylene glycol (PEG) impurities in UHPLC-MS solvent lineup (PEG S/N signal-to-noise-ratio < 50)
Preparation Note
Analysis Note
Identity (IR): conforms
Evaporation residue: ≤ 3.0 mg/l
Water: ≤ 0.03 %
Color: ≤ 10 Hazen
Acidity: ≤ 0.0002 meq/g
Alkalinity: ≤ 0.0002 meq/g
Transmission (at 225 nm): ≥ 50 %
Transmission (at 240 nm): ≥ 80 %
Transmission (from 265 nm): ≥ 98 %
Filtered by 0.2 µm filter
Other Notes
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Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificates of Analysis (COA)
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Protocols
GB method with Ascentis® Express C30 column achieves baseline resolution for Vitamin A and E critical pair.
Folic acid vs. folate differences and biological activities; implications in fortified foods and supplements for human health.
HPTLC was used to analyze caffeine in coffee. Filtration of coffee through a PTFE syringe filter was the only sample preparation. Quantitation was conducted with a TLC scanner.
Articles
Validated HPLC method (based on Ph. Eur. Monograph 2668) for quantifying catechins and caffeine in decaffeinated green tea using a Chromolith® High Resolution RP-18e column with advantages in terms of backpressure and matrix robustness.
An HPTLC method for rapid urea detection in milk using a TLC plate scanner and Silica Gel 60 F254 HPTLC plate.
Related Content
United States Pharmacopeia Methods - Benazepril
United States Pharmacopeia Methods - Betamethasone
United States Pharmacopeia Methods - Lamivudine
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 1060181000 | 04022536071701 |
| 1060189010 | 04022536071749 |
| 1060189185 | 04022536071763 |
| 1060189186 | 04054839720079 |
| 1060189910 | 04022536585017 |
| 1060182500 | 04022536071725 |
| 1060184000 | 04022536658308 |
| 1060185000 | 04022536766560 |
| 1060189030 | 04022536071756 |