약리학 및 약물 발견 연구
관련 자료
- Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.
- Target identification, validation and characterization for early stages of drug discovery. Identifying drug target via genetic association, expression profiling.
- Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication.
- 3D cell culture overview. Learn about 2D vs 3D cell culture, advantages of 3D cell culture, and techniques available to develop 3D cell models
- We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
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관련 프로토콜
- 지질 제형의 특성은 조성(양이온, 음이온, 중성 지질)에 따라 달라질 수 있지만, 조성에 상관없이 모든 지질 소포에 동일한 준비 방법을 사용할 수 있습니다. 절차의 일반적 요소에는 수화를 위한 지질 준비, 교반을 사용한 수화, 소포의 균질 분포를 위한 크기 측정이 포함됩니다.
- General Lipid/BSA solubility protocol for cell delivery. Organic solvent suspended method for the preparation of lipid stock solutions.
- Assays that predict passive absorption of orally administered drugs have become increasingly important in the drug discovery process. As previously described by Faller and Kansy such assays provide rapid, low cost and automation friendly methods to measure a compound’s passive permeability.
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