1107004
USP
Chloramphenicol
United States Pharmacopeia (USP) Reference Standard
동의어(들):
D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
CAS 번호:
Molecular Weight:
323.13
Beilstein:
2225532
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24
Grade
pharmaceutical primary standard
API family
chloramphenicol
제조업체/상표
USP
mp
149-153 °C (lit.)
응용 분야
pharmaceutical (small molecule)
형식
neat
SMILES string
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI key
WIIZWVCIJKGZOK-RKDXNWHRSA-N
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일반 설명
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Ph
애플리케이션
Chloramphenicol USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Chloramphenicol
- Chloramphenicol Injection
- Chloramphenicol Capsules
- Chloramphenicol Tablets
- Chloramphenicol Sodium Succinate
- Chloramphenicol Ophthalmic Ointment
- Chloramphenicol Compounded Oral Suspension, Veterinary
- Chloramphenicol Sodium Succinate for Injection
생화학적/생리학적 작용
Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.
Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.
Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.
Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
분석 메모
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
기타 정보
Sales restrictions may apply.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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