1019701
USP
Amiloride hydrochloride
United States Pharmacopeia (USP) Reference Standard
동의어(들):
Amiloride hydrochloride dihydrate, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C6H8ClN7O · HCl · 2H2O
CAS 번호:
Molecular Weight:
302.12
MDL number:
UNSPSC 코드:
41116107
NACRES:
NA.24
Grade
pharmaceutical primary standard
API family
amiloride
제조업체/상표
USP
응용 분야
pharmaceutical (small molecule)
형식
neat
SMILES string
Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O
InChI
1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
InChI key
LTKVFMLMEYCWMK-UHFFFAOYSA-N
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일반 설명
Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.
애플리케이션
Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Amiloride Hydrochloride and Hydrochlorothiazide Tablets
- Amiloride Hydrochloride Tablets
분석 메모
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
기타 정보
Sales restrictions may apply.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Hong Wang et al.
Hypertension (Dallas, Tex. : 1979), 62(4), 738-745 (2013-08-21)
In Dahl salt-sensitive rats (Dahl SS), glomerular capillary pressure increases in response to high salt intake and this is accompanied by significant glomerular injury compared with spontaneously hypertensive rats with similar blood pressure. Glomerular capillary pressure is controlled mainly by
Yusuke Ito et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(5), R315-R327 (2014-01-10)
Zebrafish Na(+)/H(+) exchanger 3b (zNHE3b) is highly expressed in the apical membrane of ionocytes where Na(+) is absorbed from ion-poor fresh water against a concentration gradient. Much in vivo data indicated that zNHE3b is involved in Na(+) absorption but not
Anne P Sinke et al.
American journal of physiology. Renal physiology, 306(5), F525-F533 (2013-12-20)
Lithium is the most common cause of nephrogenic diabetes insipidus (Li-NDI). Hydrochlorothiazide (HCTZ) combined with amiloride is the mainstay treatment in Li-NDI. The paradoxical antidiuretic action of HCTZ in Li-NDI is generally attributed to increased sodium and water uptake in
Shujie Shi et al.
American journal of physiology. Renal physiology, 305(11), F1585-F1592 (2013-10-11)
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits
Juraj Rievaj et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(4), G303-G313 (2013-06-15)
Intestinal calcium (Ca²⁺) absorption occurs via paracellular and transcellular pathways. Although the transcellular route has been extensively studied, mechanisms mediating paracellular absorption are largely unexplored. Unlike passive diffusion, secondarily active paracellular Ca²⁺ uptake occurs against an electrochemical gradient with water
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