U5625

Uridine 5′-diphosphoglucuronic acid ammonium salt

Name: Uridine 5′-diphosphoglucuronic acid ammonium salt
Brand: SIGMA

98-100%, from Saccharomyces cerevisiae, powder

동의어(들):

UDP-GlcA, UDPGA, Uridine-diphosphate-glucuronic acid ammonium salt, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid ammonium salt

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₅H₂₂N₂O₁₈P₂ · xNH₃

CAS 번호:

43195-60-4

Molecular Weight:

580.29 (free acid basis)

UNSPSC 코드:

41106305

PubChem Substance ID:

24900657

NACRES:

NA.51

주요 문서

모든 문서 보기

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제품 이름

Uridine 5′-diphosphoglucuronic acid ammonium salt, 98-100%

생물학적 소스

Saccharomyces cerevisiae
enzyme from bovine liver (catalase)
enzyme from rabbit muscle (LDH)

Quality Level

200

분석

98-100%

양식

powder

solubility

water: 50 mg/mL, clear, colorless

저장 온도

−20°C

SMILES string

N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1

InChI key

WMWKTCPGFOEPBD-YGIWDPDDSA-N

일반 설명

Uridine 5′-diphosphoglucuronic acid (UDPGA) is a cofactor, synthesized from UDPglucose and nicotinamide adenine dinucleotide (NAD⁺) intracellularly by the catalytic activity of UDPglucose dehydrogenase. The concentration of UDPGA in a number of liver preparations ranges from 0.3-0.5 mM.

애플리케이션

Uridine 5′-diphosphoglucuronic acid ammonium salt has been used in the initiation of UDP-glucuronosyl transferase (UDGPT) assay towards ¹⁴C-testosterone in the liver S9 protein. It is suitable for use in UDGPT assay.

생화학적/생리학적 작용

Uridine 5′-diphosphoglucuronic acid (UDGPA) is the glucuronic acid donor for the conjugation of bilirubin in the endoplasmic recticulum.

픽토그램

GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

예방조치 성명서

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1.

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Oncotarget, 8(25), 41572-41581 (2017-02-06)

SN-38, the active metabolite of irinotecan, and histone deacetylase inhibitors (HDACis) such as belinostat, vorinostat and panobinostat, have all been shown to be deactivated by glucuronidation via UGTs. Since they all compete for UGTs for deactivation, we aimed to investigate

In vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug-drug interaction risk prediction.

Hongbo Xie et al.

Xenobiotica; the fate of foreign compounds in biological systems, 47(9), 785-792 (2016-09-08)

1. Ursolic acid (UA) and oleanolic acid (OA) may have important activity relevant to health and disease prevention. Thus, we studied the activity of UA and OA on UDP-glucuronosyltransferases (UGTs) and used trifluoperazine as a probe substrate to test UGT1A4 activity.

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Journal of agricultural and food chemistry, 65(33), 7217-7227 (2017-07-25)

After being incubated with animal and human liver microsomes, metabolites of phase I and II were investigated. A comparison was performed by ultrahigh performance liquid chromatography-quadrupole/time-of-flight coupled to mass spectrometry (UHPLC-Q/TOF). Consequently, a total of four phase I metabolites and

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Uridine 5′-diphosphoglucuronic acid ammonium salt

98-100%, from Saccharomyces cerevisiae, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

생물학적 소스

Quality Level

분석

양식

solubility

저장 온도

SMILES string

InChI

InChI key

관련 카테고리

설명

일반 설명

애플리케이션

생화학적/생리학적 작용

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

표적 기관

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

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